4-Hydroxy-2,3-trans-nonenal Induces Transcription and Expression of Aldose Reductase
Treatment of A7r5 rat vascular smooth muscle cells with 4-hydroxy-2,3-trans-nonenal (HNE) resulted in increased aldose reductase mRNA transcription. Induction was time dependent, reaching a maximum (2.3-fold) after 7 hours. An enzymatically active aldose reductase analysed by Western blotting and en...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1996-09, Vol.226 (2), p.512-516 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Spycher, Stefan Tabataba-Vakili, Shirin O'Donnell, Valerie B. Palomba, Letizia Azzi, Angelo |
| description | Treatment of A7r5 rat vascular smooth muscle cells with 4-hydroxy-2,3-trans-nonenal (HNE) resulted in increased aldose reductase mRNA transcription. Induction was time dependent, reaching a maximum (2.3-fold) after 7 hours. An enzymatically active aldose reductase analysed by Western blotting and enzyme assays was expressed. Sorbinil, an aldose reductase inhibitor, induced a significant enhancement of HNE cytotoxicity, indicating a protective role of aldose reductase against HNE-induced A7r5 cell death. These data indicate that induction of aldose reductase by HNE may represent an important cellular defence mechanism against oxidative injury. |
| doi_str_mv | 10.1006/bbrc.1996.1386 |
| format | Article |
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Induction was time dependent, reaching a maximum (2.3-fold) after 7 hours. An enzymatically active aldose reductase analysed by Western blotting and enzyme assays was expressed. Sorbinil, an aldose reductase inhibitor, induced a significant enhancement of HNE cytotoxicity, indicating a protective role of aldose reductase against HNE-induced A7r5 cell death. These data indicate that induction of aldose reductase by HNE may represent an important cellular defence mechanism against oxidative injury.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.1996.1386</identifier><identifier>PMID: 8806665</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aldehyde Reductase - genetics ; Aldehyde Reductase - metabolism ; Aldehydes - pharmacology ; Animals ; Cell Line ; Cell Survival - drug effects ; Gene Expression Regulation, Enzymologic - drug effects ; Muscle, Smooth - drug effects ; Muscle, Smooth - enzymology ; Rats ; Transcription, Genetic - drug effects</subject><ispartof>Biochemical and biophysical research communications, 1996-09, Vol.226 (2), p.512-516</ispartof><rights>1996 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-b992d8e8aba0edc588ce8add213190479eec5385a44639385fc549de659e41993</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X96913868$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8806665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spycher, Stefan</creatorcontrib><creatorcontrib>Tabataba-Vakili, Shirin</creatorcontrib><creatorcontrib>O'Donnell, Valerie B.</creatorcontrib><creatorcontrib>Palomba, Letizia</creatorcontrib><creatorcontrib>Azzi, Angelo</creatorcontrib><title>4-Hydroxy-2,3-trans-nonenal Induces Transcription and Expression of Aldose Reductase</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Treatment of A7r5 rat vascular smooth muscle cells with 4-hydroxy-2,3-trans-nonenal (HNE) resulted in increased aldose reductase mRNA transcription. 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These data indicate that induction of aldose reductase by HNE may represent an important cellular defence mechanism against oxidative injury.</description><subject>Aldehyde Reductase - genetics</subject><subject>Aldehyde Reductase - metabolism</subject><subject>Aldehydes - pharmacology</subject><subject>Animals</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Gene Expression Regulation, Enzymologic - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - enzymology</subject><subject>Rats</subject><subject>Transcription, Genetic - drug effects</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMotVav3oQ9eTJrsh9pciyl2kJBkAreQjaZhZVtsia70v57s7R48zSZzDMvzIPQPSUpJYQ9V5XXKRWCpTTn7AJNKREEZ5QUl2hKIoEzQT-v0U0IX4RQWjAxQRPOCWOsnKJdgddH493hiLOnHPde2YCts2BVm2ysGTSEZDf-at90feNsoqxJVofOQwhj6-pk0RoXIHmHiPcqwC26qlUb4O5cZ-jjZbVbrvH27XWzXGyxznPR40qIzHDgqlIEjC4517ExJqM5FaSYCwBd5rxURcFyER-1LgthgJUCinhyPkOPp9zOu-8BQi_3TdDQtsqCG4Kc8xg0L1kE0xOovQvBQy073-yVP0pK5KhRjhrlqFGOGuPCwzl5qPZg_vCztzjnpznE834a8DLoBqwG03jQvTSu-S_6F6VAgTw</recordid><startdate>19960913</startdate><enddate>19960913</enddate><creator>Spycher, Stefan</creator><creator>Tabataba-Vakili, Shirin</creator><creator>O'Donnell, Valerie B.</creator><creator>Palomba, Letizia</creator><creator>Azzi, Angelo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960913</creationdate><title>4-Hydroxy-2,3-trans-nonenal Induces Transcription and Expression of Aldose Reductase</title><author>Spycher, Stefan ; Tabataba-Vakili, Shirin ; O'Donnell, Valerie B. ; Palomba, Letizia ; Azzi, Angelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-b992d8e8aba0edc588ce8add213190479eec5385a44639385fc549de659e41993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aldehyde Reductase - genetics</topic><topic>Aldehyde Reductase - metabolism</topic><topic>Aldehydes - pharmacology</topic><topic>Animals</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Gene Expression Regulation, Enzymologic - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - enzymology</topic><topic>Rats</topic><topic>Transcription, Genetic - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spycher, Stefan</creatorcontrib><creatorcontrib>Tabataba-Vakili, Shirin</creatorcontrib><creatorcontrib>O'Donnell, Valerie B.</creatorcontrib><creatorcontrib>Palomba, Letizia</creatorcontrib><creatorcontrib>Azzi, Angelo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spycher, Stefan</au><au>Tabataba-Vakili, Shirin</au><au>O'Donnell, Valerie B.</au><au>Palomba, Letizia</au><au>Azzi, Angelo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>4-Hydroxy-2,3-trans-nonenal Induces Transcription and Expression of Aldose Reductase</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1996-09-13</date><risdate>1996</risdate><volume>226</volume><issue>2</issue><spage>512</spage><epage>516</epage><pages>512-516</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Treatment of A7r5 rat vascular smooth muscle cells with 4-hydroxy-2,3-trans-nonenal (HNE) resulted in increased aldose reductase mRNA transcription. 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| ispartof | Biochemical and biophysical research communications, 1996-09, Vol.226 (2), p.512-516 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aldehyde Reductase - genetics Aldehyde Reductase - metabolism Aldehydes - pharmacology Animals Cell Line Cell Survival - drug effects Gene Expression Regulation, Enzymologic - drug effects Muscle, Smooth - drug effects Muscle, Smooth - enzymology Rats Transcription, Genetic - drug effects |
| title | 4-Hydroxy-2,3-trans-nonenal Induces Transcription and Expression of Aldose Reductase |
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