Intracellular signalling: Putting JAKs on the kinase MAP

Tyrosine kinases of the JAK family are required for activation of both STAT transcription factors and the ERK/MAP kinase pathway, suggesting a mechanism for the optimization of gene induction via the coordinate activation of multiple transcription factors.

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Bibliographische Detailangaben
Veröffentlicht in:	Current biology 1996-06, Vol.6 (6), p.668-671
Hauptverfasser:	Winston, Linda A, Hunter, Tony
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Calmodulin-Dependent Protein Kinases - metabolism Humans Janus Kinase 3 Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-raf ras Proteins - metabolism Signal Transduction - physiology Transcription Factors - metabolism Transcription, Genetic
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Beschreibung
Zusammenfassung:	Tyrosine kinases of the JAK family are required for activation of both STAT transcription factors and the ERK/MAP kinase pathway, suggesting a mechanism for the optimization of gene induction via the coordinate activation of multiple transcription factors.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/S0960-9822(09)00445-X