Efficacy of a Cell-Mediated Reaction to the Purified Protein Derivative of Tuberculin in the Disposal of Mycobacterium leprae from Human Skin

The purpose of this study was to evaluate the effects of a delayed-type cell-mediated immune response to Mycobacterium tuberculosis antigen on the Mycobacterium leprae load in the skin of leprosy patients. Twelve patients with the lepromatous form of leprosy have been injected intradermally with 5 u...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1988-07, Vol.85 (14), p.5210-5214
Hauptverfasser:	Kaplan, Gilla, Sheftel, Giulia, Job, C. K., Mathur, N. K., Nath, Indira, Cohn, Z. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antigens, Bacterial - immunology Bacterial diseases Biological and medical sciences Biopsies Dermis Giant cells Granuloma Human bacterial diseases Humans Hypersensitivity, Delayed - immunology Immunity, Cellular Infectious diseases Leprosy Leprosy - immunology Leprosy - pathology Lesions Macrophages Macrophages - immunology Macrophages - microbiology Medical sciences Microscopy, Electron Mycobacterium leprae Mycobacterium leprae - immunology Mycobacterium leprae - isolation & purification Mycobacterium tuberculosis Phagocytes - pathology Skin - immunology Skin - pathology T lymphocytes T-Lymphocytes - immunology T-Lymphocytes - pathology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - pathology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology Tropical bacterial diseases Tropical medicine Tuberculin Tuberculin Test
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Zusammenfassung:	The purpose of this study was to evaluate the effects of a delayed-type cell-mediated immune response to Mycobacterium tuberculosis antigen on the Mycobacterium leprae load in the skin of leprosy patients. Twelve patients with the lepromatous form of leprosy have been injected intradermally with 5 units of the purified protein derivative of tuberculin (PPD). Ten individuals responded with areas of induration ranging from 12 to 21 mm in diameter, and two were unresponsive (
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.85.14.5210