Influence of spasmolytic analgesics on motility of sphincter of Oddi

The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg; N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdomina...

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Veröffentlicht in:	Digestive diseases and sciences 1996-09, Vol.41 (9), p.1814-1818
Hauptverfasser:	BRANDSTÄTTER, G, SCHINZEL, S, WURZER, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Female Gastrointestinal Motility - drug effects General pharmacology Humans Male Medical sciences Middle Aged Nitroglycerin - pharmacology Parasympatholytics - pharmacology Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Single-Blind Method Sphincter of Oddi - drug effects Sphincter of Oddi - physiology
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Zusammenfassung:	The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg; N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdominal pain. Basal sphincter pressure and sphincter motility were measured for a 5-min period after treatment by endoscopic manometry. Nitroglycerin and dipyrone both caused a significant fall in basal sphincter pressure, while N-butylscopolamine and nitroglycerin produced a significant decrease in contraction frequency. Therefore, dipyrone, in contrast to tramadol and indomethacin, exhibits spasmolytic activity in addition to analgesia in biliary pain.
ISSN:	0163-2116 1573-2568
DOI:	10.1007/bf02088751