Modified substrates of DNA polymerases and design of antivirals
The results obtained in our laboratory on investigating of substrate properties of a large number of compounds towards different DNA polymerases have been summarized. On the basis of systematic analysis a directed synthesis of nucleotides with antiviral properties was performed.
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| Veröffentlicht in: | Acta biochimica polonica 1996-01, Vol.43 (1), p.125-132 |
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| container_end_page | 132 |
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| container_issue | 1 |
| container_start_page | 125 |
| container_title | Acta biochimica polonica |
| container_volume | 43 |
| creator | Krayevsky, A A Alexandrova, L A Dyatkina, N B Kukhanova, M K Shirokova, E A |
| description | The results obtained in our laboratory on investigating of substrate properties of a large number of compounds towards different DNA polymerases have been summarized. On the basis of systematic analysis a directed synthesis of nucleotides with antiviral properties was performed. |
| doi_str_mv | 10.18388/abp.1996_4523 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0001-527X |
| ispartof | Acta biochimica polonica, 1996-01, Vol.43 (1), p.125-132 |
| issn | 0001-527X 1734-154X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78307260 |
| source | Electronic Journals Library; MEDLINE; Free Full-Text Journals in Chemistry |
| subjects | AIDS/HIV Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Deoxyribonucleotides - chemical synthesis Deoxyribonucleotides - chemistry Deoxyribonucleotides - pharmacology DNA-Directed DNA Polymerase - metabolism Drug Design HIV - drug effects HIV - physiology Humans Nucleic Acid Synthesis Inhibitors Retroviridae - drug effects Reverse Transcriptase Inhibitors - chemical synthesis Reverse Transcriptase Inhibitors - pharmacology Simplexvirus - drug effects Virus Replication - drug effects |
| title | Modified substrates of DNA polymerases and design of antivirals |
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