Modified substrates of DNA polymerases and design of antivirals

The results obtained in our laboratory on investigating of substrate properties of a large number of compounds towards different DNA polymerases have been summarized. On the basis of systematic analysis a directed synthesis of nucleotides with antiviral properties was performed.

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Bibliographische Detailangaben
Veröffentlicht in:	Acta biochimica polonica 1996-01, Vol.43 (1), p.125-132
Hauptverfasser:	Krayevsky, A A, Alexandrova, L A, Dyatkina, N B, Kukhanova, M K, Shirokova, E A
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Deoxyribonucleotides - chemical synthesis Deoxyribonucleotides - chemistry Deoxyribonucleotides - pharmacology DNA-Directed DNA Polymerase - metabolism Drug Design HIV - drug effects HIV - physiology Humans Nucleic Acid Synthesis Inhibitors Retroviridae - drug effects Reverse Transcriptase Inhibitors - chemical synthesis Reverse Transcriptase Inhibitors - pharmacology Simplexvirus - drug effects Virus Replication - drug effects
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Beschreibung
Zusammenfassung:	The results obtained in our laboratory on investigating of substrate properties of a large number of compounds towards different DNA polymerases have been summarized. On the basis of systematic analysis a directed synthesis of nucleotides with antiviral properties was performed.
ISSN:	0001-527X 1734-154X
DOI:	10.18388/abp.1996_4523