Nimodipine in Acute Ischemic Stroke

To the Editor: Gelmers et al. (Jan. 28 issue) 1 have reported beneficial effects of early treatment with nimodipine in cases of acute ischemic stroke. We conducted a similar double-blind study with inclusion and exclusion criteria almost identical to those used by Gelmers et al. The diagnosis of acute stroke was confirmed by a complete neurologic workup that included a CT scan. Patients were randomly assigned to receive either oral nimodipine (30 mg four times a day) or matched placebo tablets for 28 days. The study medication was always started within 48 hours after the onset of symptoms. No concomitant standardized . . .