Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

The mechanism of CD40 ligand (CD40L)-mediated in vivo activation of CD4$^+$ T cells was examined by investigation of the development of experimental allergic encephalomyelitis (EAE) in CD40L-deficient mice that carried a transgenic T cell receptor specific for myelin basic protein. These mice failed...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1996-09, Vol.273 (5283), p.1864-1867
Hauptverfasser: Grewal, Iqbal S., Foellmer, Harald G., Grewal, Kate D., Xu, Jianchao, Hardardottir, Fridrika, Baron, Jody L., Janeway, Charles A., Flavell, Richard A.
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Sprache:eng
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Zusammenfassung:The mechanism of CD40 ligand (CD40L)-mediated in vivo activation of CD4$^+$ T cells was examined by investigation of the development of experimental allergic encephalomyelitis (EAE) in CD40L-deficient mice that carried a transgenic T cell receptor specific for myelin basic protein. These mice failed to develop EAE after priming with antigen, and CD4$^+$ T cells remained quiescent and produced no interferon-γ (IFN-γ). T cells were primed to make IFN-γ and induce EAE by providing these mice with B7.1$^+$ antigen-presenting cells (APCs). Thus, CD40L is required to induce costimulatory activity on APCs for in vivo activation of CD4$^+$ T cells to produce IFN-γ and to evoke autoimmunity.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.273.5283.1864