Dopamine receptors in Parkinson's disease

Hassan, Mohamed N. and Thakar, Jay H. Dopamine receptors in Parkinson's Disease. Prog. Neuro. Psychopharmacol. & Biol. Psychiat. 1988, 12 :173–182 1. Parkinson's disease is associated with profound decreases in striatal dopamine concentrations 2. There are significant increases in the...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 1988, Vol.12 (2), p.173-182
Hauptverfasser:	Hassan, Mohamed N., Thakar, Jay H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Caudate nucleus Corpus Striatum - metabolism D1 and D2 receptors Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases dopamine Dopamine - metabolism Humans Levodopa - therapeutic use Medical sciences Neurology Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson's disease positron emission tomography putamen Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism
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Zusammenfassung:	Hassan, Mohamed N. and Thakar, Jay H. Dopamine receptors in Parkinson's Disease. Prog. Neuro. Psychopharmacol. & Biol. Psychiat. 1988, 12 :173–182 1. Parkinson's disease is associated with profound decreases in striatal dopamine concentrations 2. There are significant increases in the densities of striatal D1 and D2 receptors as part of the compensatory mechanism 3. Levodopa therapy induces a down-regulation of both D1 and D2 receptors to normal densities 4. Positron emission tomography detects striatal changes in early Parkinson's disease or toxin-induced parkinsonism.
ISSN:	0278-5846 1878-4216
DOI:	10.1016/0278-5846(88)90035-8