MAC of I-653 in beagle dogs and New Zealand white rabbits

The minimum alveolar concentration (MAC) of I-653 was determined in six beagle dogs and four New Zealand white rabbits. The MAC values (+/- SD) were 7.2 +/- 1.0 atm % for dogs and 8.9 +/- 0.3 atm % for rabbits. Comparison of these results with published MAC values for other anesthetics indicate that...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 1988-07, Vol.69 (1), p.89-91
Hauptverfasser:	DOORLEY, B. M, WATERS, S. J, TERRELL, R. C, ROBINSON, J. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia, Inhalation Anesthetics Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Desflurane Dogs Isoflurane - analogs & derivatives Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Pulmonary Alveoli Rabbits
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Zusammenfassung:	The minimum alveolar concentration (MAC) of I-653 was determined in six beagle dogs and four New Zealand white rabbits. The MAC values (+/- SD) were 7.2 +/- 1.0 atm % for dogs and 8.9 +/- 0.3 atm % for rabbits. Comparison of these results with published MAC values for other anesthetics indicate that I-653 is one-third to one-eighth as potent as currently available volatile anesthetics (enflurane, isoflurane, and halothane). From these data and previous reports, human MAC was projected to be approximately 5.1 atm %.
ISSN:	0003-3022 1528-1175
DOI:	10.1097/00000542-198807000-00013