Virulence genes of poxviruses and reoviruses

Identification of viral genes that specify virulence, however defined, is of critical importance for the design of viral vaccines. In particular, the targeted development not only of avirulent vaccine strains but also of viruses to be used as carriers for foreign genes depends on the inactivation or...

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Veröffentlicht in:	Vaccine 1988-04, Vol.6 (2), p.123-128
Hauptverfasser:	Joklik, Wolfgang K., Pickup, David J., Patel, Dhavalkumar D., Moody, Mark D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Biotechnology Chromosome Deletion Cloning, Molecular cowpox virus DNA Restriction Enzymes - metabolism DNA, Viral - metabolism Fundamental and applied biological sciences. Psychology Genetic engineering Genetic technics Genetic Variation Genetics Mammalian orthoreovirus 3 - genetics Mammalian orthoreovirus 3 - pathogenicity Methods. Procedures. Technologies Microbiology Molecular Sequence Data poxvirus Reoviridae - genetics reovirus Vaccinia virus - genetics Vaccinia virus - pathogenicity Virology Virulence Virulence genes
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Beschreibung
Zusammenfassung:	Identification of viral genes that specify virulence, however defined, is of critical importance for the design of viral vaccines. In particular, the targeted development not only of avirulent vaccine strains but also of viruses to be used as carriers for foreign genes depends on the inactivation or deletion of genes that harm the host. This paper illustrates approaches to identifying viral pathogenesis genes in two model systems involving cowpox virus and reovirus, respectively.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/S0264-410X(88)80013-6