Hepatitis C virus types 7, 8 and 9 should be classified as type 6 subtypes
Tokita et al. reported the identification of hepatitis C virus type 7, 8 and 9 in Southeast Asia, based on the unweighed pair-group method with the artihmetic mean, a method that may not be appropriate when the nucleotide substitution rate is not constant over time. To determine more accurately the...
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Veröffentlicht in: | Journal of hepatology 1996-05, Vol.24 (5), p.622-624 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Tokita et al. reported the identification of hepatitis C virus type 7, 8 and 9 in Southeast Asia, based on the unweighed pair-group method with the artihmetic mean, a method that may not be appropriate when the nucleotide substitution rate is not constant over time. To determine more accurately the relationship of these proposed types 7, 8, and 9 with other types, a more appropriate approach, the neighbor-joining method, was applied to re-evaluate the phylogenetic relationship. A total of 660 HCV sequences, including the reported sequences, were collected from DNA databases. For every region, the nucleotide substitution rate was estimated by the 6-parameter method, and phylogenetic trees were constructed using the neighbor-joining method. The results of this analysis indicate that the newly proposed HCV types 7, 8 and 9 should be classified as type 6 subtypes. HCV type 6 appears to be diversified |
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ISSN: | 0168-8278 1600-0641 |
DOI: | 10.1016/S0168-8278(96)80149-8 |