The Xenopus laevis homologue of the 64-kDa subunit of cleavage stimulation factor

Cleavage stimulation factor (CstF) is composed of three subunits of 50, 64 and 77 kDa, respectively. We report here the identification of a cDNA clone from Xenopus laevis encoding a homologue of the 64-kDa subunit of human CstF. Comparative sequence analysis reveals that these two proteins are highl...

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Veröffentlicht in:	Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 1996-07, Vol.114 (3), p.313-315
Hauptverfasser:	Barbaux, S, Seery, L.T, Schoenberg, D.R, Sellar, G.C, Whitehead, A.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Binding Sites Blotting, Northern Cleavage stimulation factor Cloning, Molecular Conserved Sequence Freshwater Gene Expression Regulation, Developmental Humans Molecular Sequence Data mRNA Cleavage and Polyadenylation Factors Phosphorylation phosphorylation sites polyadenylation Protein Biosynthesis RNA binding domains RNA processing RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Sequence Analysis, DNA Sequence Homology, Amino Acid Xenopus CstF homologue xenopus development Xenopus laevis Xenopus laevis - embryology Xenopus laevis - physiology
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Zusammenfassung:	Cleavage stimulation factor (CstF) is composed of three subunits of 50, 64 and 77 kDa, respectively. We report here the identification of a cDNA clone from Xenopus laevis encoding a homologue of the 64-kDa subunit of human CstF. Comparative sequence analysis reveals that these two proteins are highly conserved with the exception of a unique repeat structure found in the human, but not in the X. laevis, protein. Analysis of expression of this mRNA during X. laevis tadpole development indicates a requirement for this protein throughout all stages of development.
ISSN:	1096-4959 0305-0491 1879-1107
DOI:	10.1016/0305-0491(96)00023-5