Synthesis and Antidepressant Evaluation of New Hetero[2,1]benzothiazepine Derivatives

As a part of a research program directed to the discovery of novel antidepressant agents, a series of new hetero[2,1]benzothiazepine derivatives was synthesized. Some of these compounds antagonized the ptosis and motor depression induced by tetrabenazine and were also active in the Porsolt forced sw...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 1996-07, Vol.329 (7), p.352-360
Hauptverfasser:	Díaz, Juan A., Vega, Salvador, Expósito, María A., Mateo, Candelaria C. Sánchez, Darias, Victoriano
Format:	Artikel
Sprache:	eng
Schlagworte:	1]benzothiazepine oximinoether derivatives 2-c]benzothiazepine oximino ether derivatives 4-c 4-c]benzothiazepine and thieno Animals antidepressant activity Antidepressive Agents, Tricyclic - chemical synthesis Antidepressive Agents, Tricyclic - pharmacology Behavior, Animal - drug effects Benzazepines - chemical synthesis Benzazepines - pharmacology Biological and medical sciences Body Temperature Regulation - drug effects CNS effects Female Male Medical sciences Mice Motor Activity - drug effects Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology pyrazolo pyrazolo[3,4‐c][2,1]benzothiazepine oximinoether derivatives thieno thieno[3,4‐c]benzothiazepine and thieno[3,2‐c]benzothiazepine oximino ether derivatives
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Beschreibung
Zusammenfassung:	As a part of a research program directed to the discovery of novel antidepressant agents, a series of new hetero[2,1]benzothiazepine derivatives was synthesized. Some of these compounds antagonized the ptosis and motor depression induced by tetrabenazine and were also active in the Porsolt forced swimming test.
ISSN:	0365-6233 1521-4184
DOI:	10.1002/ardp.19963290705