CGP 36 742, an orally active GABAB receptor antagonist, facilitates memory in a social recognition test in rats

CGP 36 742, an orally active GABAB receptor antagonist, improves the retention performance of rats in a social recognition test. This effect is detectable over a very wide range of doses (0.03 to 300 mg/kg, p.o.). Considering its binding (32 μmol affinity for the GABAB site) the surprisingly potent...

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Veröffentlicht in:	Behavioural brain research 1996-05, Vol.77 (1-2), p.227-229
Hauptverfasser:	Mondadori, Cesare, Moebius, Hans-Joerg, Zingg, Margrit
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Behavioral psychophysiology Biological and medical sciences Brain - drug effects CGP 36 742 Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology GABA Antagonists - pharmacology GABAB Long-Term Potentiation - drug effects Male Memory Mental Recall - drug effects Neurotransmission and behavior Organophosphorus Compounds - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rat Rats Rats, Sprague-Dawley Receptors, GABA-B - drug effects Social Behavior Social recognition
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Zusammenfassung:	CGP 36 742, an orally active GABAB receptor antagonist, improves the retention performance of rats in a social recognition test. This effect is detectable over a very wide range of doses (0.03 to 300 mg/kg, p.o.). Considering its binding (32 μmol affinity for the GABAB site) the surprisingly potent activity of CGP 36 742 makes it appear quite possible that the effect is mediated by an as yet unknown receptor subtype.
ISSN:	0166-4328 1872-7549
DOI:	10.1016/0166-4328(95)00226-X