Urodilatin (CDD/ANP-95-126) is not biologically inactivated by a peptidase from dog kidney cortex membranes in contrast to atrial natriuretic peptide/cardiodilatin (α-hANP/CDD-99-126)

Atrial natriuretic peptide (CDD/ANP-99-126) is rapidly inactivated by a membrane preparation from dog kidney cortex. Inactivation occurs by cleavage of the ring structure in the position between Cys-105 and Phe-106. A unique proteolytic product separated by HPLC on reverse-phase column appears as a...

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Veröffentlicht in:	FEBS letters 1988-06, Vol.233 (2), p.249-254
Hauptverfasser:	Gagelmann, Michael, Hock, Dieter, Forssmann, Wolf-Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Atrial Natriuretic Factor - metabolism atrial natriuretic hormone Atrial natriuretic peptide Biological activity Biological and medical sciences Cardiodilatin Cell Membrane - enzymology Diuretics - metabolism Dogs enzymes Fundamental and applied biological sciences. Psychology Kidney Cortex - enzymology Kinetics Peptide Fragments - metabolism Peptide Hydrolases - isolation & purification Peptide Hydrolases - metabolism Proteins Proteolysis Substrate Specificity Urodilatin Vascular smooth muscle, Kidney membrane
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Beschreibung
Zusammenfassung:	Atrial natriuretic peptide (CDD/ANP-99-126) is rapidly inactivated by a membrane preparation from dog kidney cortex. Inactivation occurs by cleavage of the ring structure in the position between Cys-105 and Phe-106. A unique proteolytic product separated by HPLC on reverse-phase column appears as a single peak which elutes prior the intact peptide. In contrast, CDD/ANP-95-126 (urodilatin) which is released from the kidney is not destroyed by proteolysis using an identical membrane preparation.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(88)80436-8