Family of human Na +,K +-ATPase genes Structure of the gene for the catalytic subunit (αIII-form) and its relationship with structural features of the protein

The primary structure of a gene of the Na +,K +-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical αIII-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possib...

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Veröffentlicht in:FEBS letters 1988-06, Vol.233 (1), p.87-94
Hauptverfasser: Ovchinnikov, Yu.A., Monastyrskaya, G.S., Broude, N.E., Ushkaryov, Yu.A., Melkov, A.M., Smirnov, Yu.V., Malyshev, I.V., Allikmets, R.L., Kostina, M.B., Dulubova, I.E., Kiyatkin, N.I., Grishin, A.V., Modyanov, N.N., Sverdlov, E.D.
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container_end_page 94
container_issue 1
container_start_page 87
container_title FEBS letters
container_volume 233
creator Ovchinnikov, Yu.A.
Monastyrskaya, G.S.
Broude, N.E.
Ushkaryov, Yu.A.
Melkov, A.M.
Smirnov, Yu.V.
Malyshev, I.V.
Allikmets, R.L.
Kostina, M.B.
Dulubova, I.E.
Kiyatkin, N.I.
Grishin, A.V.
Modyanov, N.N.
Sverdlov, E.D.
description The primary structure of a gene of the Na +,K +-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical αIII-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location of introns in the gene are discussed.
doi_str_mv 10.1016/0014-5793(88)81361-9
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Genome</subject><subject>Humans</subject><subject>Introns</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Na +,K +-ATPase</subject><subject>Protein spatial organization</subject><subject>Sodium-Potassium-Exchanging ATPase - genetics</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd1u1DAQhSMEKkvhDUDyBUKtSiCOk3h8g9RWXVhRARLl2nKcMWuUn63tUO3T9Bl4EZ4JZ7PsJeLKmplvzpHPJMlzmr2hGa3eZhkt0pILdgJwCpRVNBUPkgUFzlJWVPAwWRyQx8kT739ksQYqjpKjHBiwXCyS-6XqbLslgyHrsVM9-aTI2euP5Cw9v_miPJLv2KMnX4MbdRgdTmBYz21iBrcrtAqq3QariR_rsbeBnPz-tVqt0gh0p0T1DbHBE4etCnbo_dpuyJ0Na-L3sqolBtWk7_8abNwQ0PZPk0dGtR6f7d_j5Nvy6ubyQ3r9-f3q8vw61YUoRWo41bypDEDBECgYzipuWFNDKURJyxgYouZQ8zyjtYbGZHUt0EBV1qyJ4R0nr2bd6Hs7og-ys15j26oeh9FLDnnFK8ojWMygdoP3Do3cONspt5U0k9Nd5BS6nEKXAHJ3Fyni2ou9_lh32ByW9oeI85f7ufJatcapXlt_wDgtMp6ziC1n7M62uP0va7m8usinwdQH2HUnv3ezEMZQf1p00muLvcbGOtRBNoP994f-AMjgvdc</recordid><startdate>19880606</startdate><enddate>19880606</enddate><creator>Ovchinnikov, Yu.A.</creator><creator>Monastyrskaya, G.S.</creator><creator>Broude, N.E.</creator><creator>Ushkaryov, Yu.A.</creator><creator>Melkov, A.M.</creator><creator>Smirnov, Yu.V.</creator><creator>Malyshev, I.V.</creator><creator>Allikmets, R.L.</creator><creator>Kostina, M.B.</creator><creator>Dulubova, I.E.</creator><creator>Kiyatkin, N.I.</creator><creator>Grishin, A.V.</creator><creator>Modyanov, N.N.</creator><creator>Sverdlov, E.D.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880606</creationdate><title>Family of human Na +,K +-ATPase genes Structure of the gene for the catalytic subunit (αIII-form) and its relationship with structural features of the protein</title><author>Ovchinnikov, Yu.A. ; Monastyrskaya, G.S. ; Broude, N.E. ; Ushkaryov, Yu.A. ; Melkov, A.M. ; Smirnov, Yu.V. ; Malyshev, I.V. ; Allikmets, R.L. ; Kostina, M.B. ; Dulubova, I.E. ; Kiyatkin, N.I. ; Grishin, A.V. ; Modyanov, N.N. ; Sverdlov, E.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4959-f71c7d6f8843e818f7367f3db8599515101eec78b7201bc8df0bb9ef865b3d813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Bacteriophage lambda - genetics</topic><topic>Base Composition</topic><topic>Base Sequence</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Catalysis</topic><topic>Catalytic subunit</topic><topic>DNA - genetics</topic><topic>DNA, Recombinant</topic><topic>Exon/intron structure</topic><topic>Exons</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene sequence</topic><topic>Genes. Genome</topic><topic>Humans</topic><topic>Introns</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Na +,K +-ATPase</topic><topic>Protein spatial organization</topic><topic>Sodium-Potassium-Exchanging ATPase - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ovchinnikov, Yu.A.</creatorcontrib><creatorcontrib>Monastyrskaya, G.S.</creatorcontrib><creatorcontrib>Broude, N.E.</creatorcontrib><creatorcontrib>Ushkaryov, Yu.A.</creatorcontrib><creatorcontrib>Melkov, A.M.</creatorcontrib><creatorcontrib>Smirnov, Yu.V.</creatorcontrib><creatorcontrib>Malyshev, I.V.</creatorcontrib><creatorcontrib>Allikmets, R.L.</creatorcontrib><creatorcontrib>Kostina, M.B.</creatorcontrib><creatorcontrib>Dulubova, I.E.</creatorcontrib><creatorcontrib>Kiyatkin, N.I.</creatorcontrib><creatorcontrib>Grishin, A.V.</creatorcontrib><creatorcontrib>Modyanov, N.N.</creatorcontrib><creatorcontrib>Sverdlov, E.D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ovchinnikov, Yu.A.</au><au>Monastyrskaya, G.S.</au><au>Broude, N.E.</au><au>Ushkaryov, Yu.A.</au><au>Melkov, A.M.</au><au>Smirnov, Yu.V.</au><au>Malyshev, I.V.</au><au>Allikmets, R.L.</au><au>Kostina, M.B.</au><au>Dulubova, I.E.</au><au>Kiyatkin, N.I.</au><au>Grishin, A.V.</au><au>Modyanov, N.N.</au><au>Sverdlov, E.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Family of human Na +,K +-ATPase genes Structure of the gene for the catalytic subunit (αIII-form) and its relationship with structural features of the protein</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1988-06-06</date><risdate>1988</risdate><volume>233</volume><issue>1</issue><spage>87</spage><epage>94</epage><pages>87-94</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>The primary structure of a gene of the Na +,K +-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical αIII-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location of introns in the gene are discussed.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2838329</pmid><doi>10.1016/0014-5793(88)81361-9</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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ispartof FEBS letters, 1988-06, Vol.233 (1), p.87-94
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language eng
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source MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Amino Acid Sequence
Animals
Bacteriophage lambda - genetics
Base Composition
Base Sequence
Binding Sites
Biological and medical sciences
Catalysis
Catalytic subunit
DNA - genetics
DNA, Recombinant
Exon/intron structure
Exons
Fundamental and applied biological sciences. Psychology
Gene sequence
Genes. Genome
Humans
Introns
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Na +,K +-ATPase
Protein spatial organization
Sodium-Potassium-Exchanging ATPase - genetics
title Family of human Na +,K +-ATPase genes Structure of the gene for the catalytic subunit (αIII-form) and its relationship with structural features of the protein
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