Family of human Na +,K +-ATPase genes Structure of the gene for the catalytic subunit (αIII-form) and its relationship with structural features of the protein
The primary structure of a gene of the Na +,K +-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical αIII-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possib...
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Veröffentlicht in: | FEBS letters 1988-06, Vol.233 (1), p.87-94 |
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creator | Ovchinnikov, Yu.A. Monastyrskaya, G.S. Broude, N.E. Ushkaryov, Yu.A. Melkov, A.M. Smirnov, Yu.V. Malyshev, I.V. Allikmets, R.L. Kostina, M.B. Dulubova, I.E. Kiyatkin, N.I. Grishin, A.V. Modyanov, N.N. Sverdlov, E.D. |
description | The primary structure of a gene of the Na
+,K
+-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical αIII-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location of introns in the gene are discussed. |
doi_str_mv | 10.1016/0014-5793(88)81361-9 |
format | Article |
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+,K
+-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical αIII-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location of introns in the gene are discussed.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(88)81361-9</identifier><identifier>PMID: 2838329</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Bacteriophage lambda - genetics ; Base Composition ; Base Sequence ; Binding Sites ; Biological and medical sciences ; Catalysis ; Catalytic subunit ; DNA - genetics ; DNA, Recombinant ; Exon/intron structure ; Exons ; Fundamental and applied biological sciences. Psychology ; Gene sequence ; Genes. Genome ; Humans ; Introns ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Na +,K +-ATPase ; Protein spatial organization ; Sodium-Potassium-Exchanging ATPase - genetics</subject><ispartof>FEBS letters, 1988-06, Vol.233 (1), p.87-94</ispartof><rights>1988</rights><rights>FEBS Letters 233 (1988) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4959-f71c7d6f8843e818f7367f3db8599515101eec78b7201bc8df0bb9ef865b3d813</citedby><cites>FETCH-LOGICAL-c4959-f71c7d6f8843e818f7367f3db8599515101eec78b7201bc8df0bb9ef865b3d813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014579388813619$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7140723$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2838329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ovchinnikov, Yu.A.</creatorcontrib><creatorcontrib>Monastyrskaya, G.S.</creatorcontrib><creatorcontrib>Broude, N.E.</creatorcontrib><creatorcontrib>Ushkaryov, Yu.A.</creatorcontrib><creatorcontrib>Melkov, A.M.</creatorcontrib><creatorcontrib>Smirnov, Yu.V.</creatorcontrib><creatorcontrib>Malyshev, I.V.</creatorcontrib><creatorcontrib>Allikmets, R.L.</creatorcontrib><creatorcontrib>Kostina, M.B.</creatorcontrib><creatorcontrib>Dulubova, I.E.</creatorcontrib><creatorcontrib>Kiyatkin, N.I.</creatorcontrib><creatorcontrib>Grishin, A.V.</creatorcontrib><creatorcontrib>Modyanov, N.N.</creatorcontrib><creatorcontrib>Sverdlov, E.D.</creatorcontrib><title>Family of human Na +,K +-ATPase genes Structure of the gene for the catalytic subunit (αIII-form) and its relationship with structural features of the protein</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The primary structure of a gene of the Na
+,K
+-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical αIII-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location of introns in the gene are discussed.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Bacteriophage lambda - genetics</subject><subject>Base Composition</subject><subject>Base Sequence</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Catalysis</subject><subject>Catalytic subunit</subject><subject>DNA - genetics</subject><subject>DNA, Recombinant</subject><subject>Exon/intron structure</subject><subject>Exons</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene sequence</subject><subject>Genes. Genome</subject><subject>Humans</subject><subject>Introns</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Na +,K +-ATPase</subject><subject>Protein spatial organization</subject><subject>Sodium-Potassium-Exchanging ATPase - genetics</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd1u1DAQhSMEKkvhDUDyBUKtSiCOk3h8g9RWXVhRARLl2nKcMWuUn63tUO3T9Bl4EZ4JZ7PsJeLKmplvzpHPJMlzmr2hGa3eZhkt0pILdgJwCpRVNBUPkgUFzlJWVPAwWRyQx8kT739ksQYqjpKjHBiwXCyS-6XqbLslgyHrsVM9-aTI2euP5Cw9v_miPJLv2KMnX4MbdRgdTmBYz21iBrcrtAqq3QariR_rsbeBnPz-tVqt0gh0p0T1DbHBE4etCnbo_dpuyJ0Na-L3sqolBtWk7_8abNwQ0PZPk0dGtR6f7d_j5Nvy6ubyQ3r9-f3q8vw61YUoRWo41bypDEDBECgYzipuWFNDKURJyxgYouZQ8zyjtYbGZHUt0EBV1qyJ4R0nr2bd6Hs7og-ys15j26oeh9FLDnnFK8ojWMygdoP3Do3cONspt5U0k9Nd5BS6nEKXAHJ3Fyni2ou9_lh32ByW9oeI85f7ufJatcapXlt_wDgtMp6ziC1n7M62uP0va7m8usinwdQH2HUnv3ezEMZQf1p00muLvcbGOtRBNoP994f-AMjgvdc</recordid><startdate>19880606</startdate><enddate>19880606</enddate><creator>Ovchinnikov, Yu.A.</creator><creator>Monastyrskaya, G.S.</creator><creator>Broude, N.E.</creator><creator>Ushkaryov, Yu.A.</creator><creator>Melkov, A.M.</creator><creator>Smirnov, Yu.V.</creator><creator>Malyshev, I.V.</creator><creator>Allikmets, R.L.</creator><creator>Kostina, M.B.</creator><creator>Dulubova, I.E.</creator><creator>Kiyatkin, N.I.</creator><creator>Grishin, A.V.</creator><creator>Modyanov, N.N.</creator><creator>Sverdlov, E.D.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880606</creationdate><title>Family of human Na +,K +-ATPase genes Structure of the gene for the catalytic subunit (αIII-form) and its relationship with structural features of the protein</title><author>Ovchinnikov, Yu.A. ; Monastyrskaya, G.S. ; Broude, N.E. ; Ushkaryov, Yu.A. ; Melkov, A.M. ; Smirnov, Yu.V. ; Malyshev, I.V. ; Allikmets, R.L. ; Kostina, M.B. ; Dulubova, I.E. ; Kiyatkin, N.I. ; Grishin, A.V. ; Modyanov, N.N. ; Sverdlov, E.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4959-f71c7d6f8843e818f7367f3db8599515101eec78b7201bc8df0bb9ef865b3d813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Bacteriophage lambda - genetics</topic><topic>Base Composition</topic><topic>Base Sequence</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Catalysis</topic><topic>Catalytic subunit</topic><topic>DNA - genetics</topic><topic>DNA, Recombinant</topic><topic>Exon/intron structure</topic><topic>Exons</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene sequence</topic><topic>Genes. Genome</topic><topic>Humans</topic><topic>Introns</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Na +,K +-ATPase</topic><topic>Protein spatial organization</topic><topic>Sodium-Potassium-Exchanging ATPase - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ovchinnikov, Yu.A.</creatorcontrib><creatorcontrib>Monastyrskaya, G.S.</creatorcontrib><creatorcontrib>Broude, N.E.</creatorcontrib><creatorcontrib>Ushkaryov, Yu.A.</creatorcontrib><creatorcontrib>Melkov, A.M.</creatorcontrib><creatorcontrib>Smirnov, Yu.V.</creatorcontrib><creatorcontrib>Malyshev, I.V.</creatorcontrib><creatorcontrib>Allikmets, R.L.</creatorcontrib><creatorcontrib>Kostina, M.B.</creatorcontrib><creatorcontrib>Dulubova, I.E.</creatorcontrib><creatorcontrib>Kiyatkin, N.I.</creatorcontrib><creatorcontrib>Grishin, A.V.</creatorcontrib><creatorcontrib>Modyanov, N.N.</creatorcontrib><creatorcontrib>Sverdlov, E.D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ovchinnikov, Yu.A.</au><au>Monastyrskaya, G.S.</au><au>Broude, N.E.</au><au>Ushkaryov, Yu.A.</au><au>Melkov, A.M.</au><au>Smirnov, Yu.V.</au><au>Malyshev, I.V.</au><au>Allikmets, R.L.</au><au>Kostina, M.B.</au><au>Dulubova, I.E.</au><au>Kiyatkin, N.I.</au><au>Grishin, A.V.</au><au>Modyanov, N.N.</au><au>Sverdlov, E.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Family of human Na +,K +-ATPase genes Structure of the gene for the catalytic subunit (αIII-form) and its relationship with structural features of the protein</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1988-06-06</date><risdate>1988</risdate><volume>233</volume><issue>1</issue><spage>87</spage><epage>94</epage><pages>87-94</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>The primary structure of a gene of the Na
+,K
+-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical αIII-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location of introns in the gene are discussed.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2838329</pmid><doi>10.1016/0014-5793(88)81361-9</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
subjects | Amino Acid Sequence Animals Bacteriophage lambda - genetics Base Composition Base Sequence Binding Sites Biological and medical sciences Catalysis Catalytic subunit DNA - genetics DNA, Recombinant Exon/intron structure Exons Fundamental and applied biological sciences. Psychology Gene sequence Genes. Genome Humans Introns Molecular and cellular biology Molecular genetics Molecular Sequence Data Na +,K +-ATPase Protein spatial organization Sodium-Potassium-Exchanging ATPase - genetics |
title | Family of human Na +,K +-ATPase genes Structure of the gene for the catalytic subunit (αIII-form) and its relationship with structural features of the protein |
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