Family of human Na +,K +-ATPase genes Structure of the gene for the catalytic subunit (αIII-form) and its relationship with structural features of the protein

The primary structure of a gene of the Na +,K +-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical αIII-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possib...

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Veröffentlicht in:	FEBS letters 1988-06, Vol.233 (1), p.87-94
Hauptverfasser:	Ovchinnikov, Yu.A., Monastyrskaya, G.S., Broude, N.E., Ushkaryov, Yu.A., Melkov, A.M., Smirnov, Yu.V., Malyshev, I.V., Allikmets, R.L., Kostina, M.B., Dulubova, I.E., Kiyatkin, N.I., Grishin, A.V., Modyanov, N.N., Sverdlov, E.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bacteriophage lambda - genetics Base Composition Base Sequence Binding Sites Biological and medical sciences Catalysis Catalytic subunit DNA - genetics DNA, Recombinant Exon/intron structure Exons Fundamental and applied biological sciences. Psychology Gene sequence Genes. Genome Humans Introns Molecular and cellular biology Molecular genetics Molecular Sequence Data Na +,K +-ATPase Protein spatial organization Sodium-Potassium-Exchanging ATPase - genetics
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Zusammenfassung:	The primary structure of a gene of the Na +,K +-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical αIII-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location of introns in the gene are discussed.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(88)81361-9