Involvement of annexin V in the entry of influenza viruses and role of phospholipids in infection

Influenza viruses bind to annexin V, a widely spread non-glycosylated phospholipid-binding protein. Externally added phospholipids as well as antiserum against this protein specifically inhibit infection of these viruses in cell cultures. We conclude that annexin V plays an important role in the ent...

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Veröffentlicht in:	FEBS letters 1996-08, Vol.392 (1), p.59-62
Hauptverfasser:	Huang, Richard T.C., Lichtenberg, Beate, Rick, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin Annexin A5 - metabolism Antibodies, Viral - immunology Binding protein Capsid - metabolism Cell Line Dogs Humans Influenza A virus Influenza A virus - immunology Influenza A virus - metabolism Influenza A virus - pathogenicity Influenza virus Phosphatidylethanolamines - metabolism Phospholipid Phospholipids - metabolism Receptor Receptors, Virus - metabolism Recombinant Fusion Proteins - metabolism Time Factors Viral Core Proteins - metabolism Viral Plaque Assay
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Beschreibung
Zusammenfassung:	Influenza viruses bind to annexin V, a widely spread non-glycosylated phospholipid-binding protein. Externally added phospholipids as well as antiserum against this protein specifically inhibit infection of these viruses in cell cultures. We conclude that annexin V plays an important role in the entry of these viruses.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(96)00783-1