Novel Azacyclic Ureas That Are Potent Inhibitors of HIV-1 Protease

A series of novel, azacyclic ureas which are highly potent inhibitors of the HIV-1 protease (IC50= 4.1 to

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 1996-08, Vol.225 (2), p.436-440
Hauptverfasser:	Sham, Hing L., Zhao, Chen, Marsh, Kennan C., Betebenner, David A., Lin, Shuqun, Jr, William Rosenbrook, Herrin, Thomas, Li, Leping, Madigan, Darold, Vasavanonda, Suthida, Molla, Akhter, Saldivar, Ayda, McDonald, Edith, Wideburg, Norman E., Kempf, Dale, Norbeck, Daniel W., Plattner, Jacob J.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Animals Biological Availability Cell Line HIV Protease - genetics HIV Protease Inhibitors - chemical synthesis HIV Protease Inhibitors - pharmacokinetics HIV Protease Inhibitors - pharmacology HIV-1 - enzymology human immunodeficiency virus 1 Humans Male Molecular Sequence Data Rats Rats, Sprague-Dawley Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - genetics Urea - analogs & derivatives Urea - chemical synthesis Urea - pharmacokinetics Urea - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A series of novel, azacyclic ureas which are highly potent inhibitors of the HIV-1 protease (IC50= 4.1 to
ISSN:	0006-291X 1090-2104
DOI:	10.1006/bbrc.1996.1191