Biochemical Studies on Mammalian Lipoxygenases

The arachidonate cascade provides biochemists with a number of materials of enzymological interest. Mammalian tissues have several lipoxygenases, each with a positional and stereochemical specificity of arachidonate oxygenation. Some lipoxygenases are involved in the synthesis of bioactive oxyeicosa...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 1988, Vol.524 (1), p.12-26
Hauptverfasser:	YAMAMOTO, SHOZO, UEDA, NATSUO, EHARA, HIROAKI, MARUYAMA, TAKAYUKI, YOKOYAMA, CHIEKO, KANEKO, SHUJI, YOSHIMOTO, TANIHIRO, KOMATSU, NORIYUKI, WATANABE, KEIICHI, HATTORI, AKIRA, FITZSIMMONS, BRIAN J., ROKACH, JOSHUA, BRASH, ALAN R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonate 12-Lipoxygenase - isolation & purification Arachidonate 12-Lipoxygenase - metabolism Arachidonate 5-Lipoxygenase - isolation & purification Arachidonate 5-Lipoxygenase - metabolism Arachidonic Acids - metabolism Enzyme-Linked Immunosorbent Assay Female Humans Immunoenzyme Techniques Leukocytes - enzymology lipoxygenase Lipoxygenase - metabolism mammalian cells Mammals - metabolism Middle Aged Prostaglandin-Endoperoxide Synthases - deficiency
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Beschreibung
Zusammenfassung:	The arachidonate cascade provides biochemists with a number of materials of enzymological interest. Mammalian tissues have several lipoxygenases, each with a positional and stereochemical specificity of arachidonate oxygenation. Some lipoxygenases are involved in the synthesis of bioactive oxyeicosanoids, while others are still of unknown physiological significance. Fatty acid cyclooxygenase is an atypical lipoxygenase incorporating two molecules of oxygen into arachidonic acid and producing a prostaglandin peroxide.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.1988.tb38527.x