Riluzole, a glutamate antagonist, enhances slow wave and REM sleep in rats

Riluzole is a drug that interferes with glutamate neurotransmission. We studied the sleep pattern of rats treated orally with riluzole at doses ranging from 0.5 to 8 mg/kg. Duration of slow wave sleep and rapid eye movement sleep was found to increase in a dose-dependent manner from 1 mg/kg, at the...

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Veröffentlicht in:	Neuroscience letters 1988-05, Vol.88 (2), p.195-200
Hauptverfasser:	Stutzmann, J.M., Lucas, M., Blanchard, J.C., Laduron, P.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dose-Response Relationship, Drug Electrocorticogram Fundamental and applied biological sciences. Psychology Glutamate antagonist Male Rapid eye movement sleep Rat Rats Rats, Inbred Strains Receptors, Glutamate Receptors, Neurotransmitter - drug effects Receptors, Neurotransmitter - physiology Riluzole Sleep - drug effects Sleep, REM - drug effects Sleep. Vigilance Slow wave sleep Thiazoles - pharmacology Time Factors Vertebrates: nervous system and sense organs
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Zusammenfassung:	Riluzole is a drug that interferes with glutamate neurotransmission. We studied the sleep pattern of rats treated orally with riluzole at doses ranging from 0.5 to 8 mg/kg. Duration of slow wave sleep and rapid eye movement sleep was found to increase in a dose-dependent manner from 1 mg/kg, at the expense of awakeness. These data suggest that glutamate neurotransmission may be involved in the regulation of sleep. Riluzole can be of interest as sleep modulator, in particular in psychiatric disorders.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(88)90125-5