Strain-specific development of the mossy fiber system in organotypic cultures of the mouse hippocampus

The postnatal development of the hippocampus of the inbred mice strains BALB/c, C57BL/6, and DBA/2 was studied in organotypic explant cultures using the roller-tube technique. In vivo, mice exhibit strain-specific mossy fiber distribution patterns. As a main result we found, that after cultivation o...

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Veröffentlicht in:Neuroscience letters 1988-04, Vol.87 (1), p.7-10
Hauptverfasser: Schwegler, H., Heimrich, B., Keller, F., Renner, P., Crusio, W.E.
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Sprache:eng
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Zusammenfassung:The postnatal development of the hippocampus of the inbred mice strains BALB/c, C57BL/6, and DBA/2 was studied in organotypic explant cultures using the roller-tube technique. In vivo, mice exhibit strain-specific mossy fiber distribution patterns. As a main result we found, that after cultivation of 3–4 weeks, similar strain-specific patterns became apparent in vitro, as visualized by a modified Timm staining. From this experiment we can conclude that a postnatal extrinsic influence cannot be the cause of the strain-specific hippocampal features.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(88)90136-X