Immunocytochemistry of a vasopressin (AVP) receptor with anti-idiotype antibody: Inhibition of staining with a peptide (PVA) encoded by an RNA that is complementary to AVP mRNA

Immunocytochemical staining of putative presynaptic (auto-) receptors associated with vasopressin (AVP) neurons by anti-idiotype antibody can be markedly reduced or abolished by preincubation of the antibody with peptide PVA. This peptide, Ser-Ser-Trp-Ala-Val-Leu-Glu-Val-Ala, represents amino acids...

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Veröffentlicht in:	Neuroscience letters 1988-04, Vol.86 (3), p.269-271
Hauptverfasser:	Knigge, Karl M., Piekut, Diane T., Berlove, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-idiotype antibody Biological and medical sciences Cell receptors Cell structures and functions Complementary RNA Fundamental and applied biological sciences. Psychology Immunoglobulin Idiotypes Immunohistochemistry Male Molecular and cellular biology Oligopeptides - metabolism Peptide PVA Rats Rats, Inbred Strains Receptor immunocytochemistry Receptors, Angiotensin - immunology Receptors, Angiotensin - metabolism Receptors, Vasopressin RNA, Messenger - metabolism Vasopressin (AVP)
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Zusammenfassung:	Immunocytochemical staining of putative presynaptic (auto-) receptors associated with vasopressin (AVP) neurons by anti-idiotype antibody can be markedly reduced or abolished by preincubation of the antibody with peptide PVA. This peptide, Ser-Ser-Trp-Ala-Val-Leu-Glu-Val-Ala, represents amino acids encoded by a nucleotide sequence complementary to the mRNA code of AVP. These results suggest that PVA may have some binding characteristics similar to the AVP autoreceptor.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(88)90494-6