Effect of 8-methoxypsoralen and 4,5'-dimethylangelicin on ribonucleic acid synthesis in vitro
Photobinding of 8-methoxypsoralen (8-MOP) to DNA leads to mono- and diadduct formation while 4,5'-dimethylangelicin (4,5'-DMA) binds monofunctionally. The effect of the irreversible binding of furocoumarins to DNA on different steps of RNA synthesis has been assayed in this study.
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| Veröffentlicht in: | Biochemical pharmacology 1988-05, Vol.37 (9), p.1827-1828 |
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| container_end_page | 1828 |
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| container_issue | 9 |
| container_start_page | 1827 |
| container_title | Biochemical pharmacology |
| container_volume | 37 |
| creator | Czyz, M Piestrzeniewicz, K Wilmańska, D Studzian, K Szmigiero, L Gniazdowski, M |
| description | Photobinding of 8-methoxypsoralen (8-MOP) to DNA leads to mono- and diadduct formation while 4,5'-dimethylangelicin (4,5'-DMA) binds monofunctionally. The effect of the irreversible binding of furocoumarins to DNA on different steps of RNA synthesis has been assayed in this study. |
| doi_str_mv | 10.1016/0006-2952(88)90466-2 |
| format | Article |
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The effect of the irreversible binding of furocoumarins to DNA on different steps of RNA synthesis has been assayed in this study.</description><subject>DNA-Directed RNA Polymerases - antagonists & inhibitors</subject><subject>Escherichia coli</subject><subject>Furocoumarins - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Methoxsalen - pharmacology</subject><subject>RNA - biosynthesis</subject><subject>Templates, Genetic</subject><issn>0006-2952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhH0AlVL4ByD5xEMiYDt-9Yiq8pAqcYEjshJ7Q42SuMQJIv-ehFa9clrN7sxo9SF0RsktJVTeEUJkwuaCXWl9PSdcDuoATffrI3Qc4-cotaQTNGFccErlFL0viwJsi0OBdVJBuw4__SaGJiuhxlntML8Rl4nz46kvs_oDSm99jUONG5-HurMleIsz6x2Ofd2uIfqIB8O3b5twgg6LrIxwupsz9PawfF08JauXx-fF_SqxjOs2EXmmnM41IUoAVZYp4TgQaklROCWdyueUgEy1tUB5amXOFWUp4wxSLQVPZ-hi27tpwlcHsTWVjxbK4WEIXTRKMzGU63-NVFBGNFWDkW-NtgkxNlCYTeOrrOkNJWZEbkaYZmRrtDZ_yA0bYue7_i6vwO1DO97pL9WKfYE</recordid><startdate>19880501</startdate><enddate>19880501</enddate><creator>Czyz, M</creator><creator>Piestrzeniewicz, K</creator><creator>Wilmańska, D</creator><creator>Studzian, K</creator><creator>Szmigiero, L</creator><creator>Gniazdowski, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>19880501</creationdate><title>Effect of 8-methoxypsoralen and 4,5'-dimethylangelicin on ribonucleic acid synthesis in vitro</title><author>Czyz, M ; Piestrzeniewicz, K ; Wilmańska, D ; Studzian, K ; Szmigiero, L ; Gniazdowski, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c248t-5ba7d8b80075e17c275d4e01c0ffd76d7b910e638cce143c6b47123242e386543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>DNA-Directed RNA Polymerases - antagonists & inhibitors</topic><topic>Escherichia coli</topic><topic>Furocoumarins - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Methoxsalen - pharmacology</topic><topic>RNA - biosynthesis</topic><topic>Templates, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Czyz, M</creatorcontrib><creatorcontrib>Piestrzeniewicz, K</creatorcontrib><creatorcontrib>Wilmańska, D</creatorcontrib><creatorcontrib>Studzian, K</creatorcontrib><creatorcontrib>Szmigiero, L</creatorcontrib><creatorcontrib>Gniazdowski, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Czyz, M</au><au>Piestrzeniewicz, K</au><au>Wilmańska, D</au><au>Studzian, K</au><au>Szmigiero, L</au><au>Gniazdowski, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of 8-methoxypsoralen and 4,5'-dimethylangelicin on ribonucleic acid synthesis in vitro</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1988-05-01</date><risdate>1988</risdate><volume>37</volume><issue>9</issue><spage>1827</spage><epage>1828</epage><pages>1827-1828</pages><issn>0006-2952</issn><abstract>Photobinding of 8-methoxypsoralen (8-MOP) to DNA leads to mono- and diadduct formation while 4,5'-dimethylangelicin (4,5'-DMA) binds monofunctionally. 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| fulltext | fulltext |
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| ispartof | Biochemical pharmacology, 1988-05, Vol.37 (9), p.1827-1828 |
| issn | 0006-2952 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | DNA-Directed RNA Polymerases - antagonists & inhibitors Escherichia coli Furocoumarins - pharmacology In Vitro Techniques Methoxsalen - pharmacology RNA - biosynthesis Templates, Genetic |
| title | Effect of 8-methoxypsoralen and 4,5'-dimethylangelicin on ribonucleic acid synthesis in vitro |
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