Effect of 8-methoxypsoralen and 4,5'-dimethylangelicin on ribonucleic acid synthesis in vitro

Effect of 8-methoxypsoralen and 4,5'-dimethylangelicin on ribonucleic acid synthesis in vitro

Photobinding of 8-methoxypsoralen (8-MOP) to DNA leads to mono- and diadduct formation while 4,5'-dimethylangelicin (4,5'-DMA) binds monofunctionally. The effect of the irreversible binding of furocoumarins to DNA on different steps of RNA synthesis has been assayed in this study.

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Veröffentlicht in:Biochemical pharmacology 1988-05, Vol.37 (9), p.1827-1828
Hauptverfasser: Czyz, M, Piestrzeniewicz, K, Wilmańska, D, Studzian, K, Szmigiero, L, Gniazdowski, M
Format: Artikel
Sprache:eng
Schlagworte:
DNA-Directed RNA Polymerases - antagonists & inhibitors
Escherichia coli
Furocoumarins - pharmacology
In Vitro Techniques
Methoxsalen - pharmacology
RNA - biosynthesis
Templates, Genetic
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Zusammenfassung:Photobinding of 8-methoxypsoralen (8-MOP) to DNA leads to mono- and diadduct formation while 4,5'-dimethylangelicin (4,5'-DMA) binds monofunctionally. The effect of the irreversible binding of furocoumarins to DNA on different steps of RNA synthesis has been assayed in this study.
ISSN:0006-2952
DOI:10.1016/0006-2952(88)90466-2