Acute and chronic effects of morphine in pigeons responding under a progressive-ratio schedule of food delivery

Although progressive-ratio schedules have often been used by behavioral pharmacologists to index the relative reinforcing effects of drugs of abuse, they have been ignored in the study of tolerance to opioids. The present study examined tolerance to morphine in pigeons responding under a progressive-ratio 5 schedule of food delivery. Acute administrations of morphine produced general dose-dependent reductions in response rates and breaking points. Dose-response curves for both measures shifted rightward substantially (roughly fivefold) following chronic (daily) exposure to morphine, indicating that tolerance developed to the drug's effects.