Increase in vasopressin binding sites in the human choroid plexus in Alzheimer's disease

Vasopressin binding sites were determined in the choroid plexus of five Alzheimer's disease patients and five non-demented controls using the 125I-labelled linear V 1a-antagonist. The Alzheimer's disease patients showed a twofold increase in the density of vasopressin binding sites, wherea...

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Veröffentlicht in:	Brain research 1996-01, Vol.706 (1), p.151-154
Hauptverfasser:	Korting, C., van Zwieten, E.J., Boer, G.J., Ravid, R., Swaab, D.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer's disease Amino Acid Sequence Biological and medical sciences Cerebrospinal fluid Choroid Plexus - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Human brain Humans Linear V1 a-antagonist choroid plexus Male Medical sciences Middle Aged Molecular Sequence Data Neurology Receptors, Vasopressin - metabolism Vasopressin binding sites
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Zusammenfassung:	Vasopressin binding sites were determined in the choroid plexus of five Alzheimer's disease patients and five non-demented controls using the 125I-labelled linear V 1a-antagonist. The Alzheimer's disease patients showed a twofold increase in the density of vasopressin binding sites, whereas the increase in the affinity constant K d did not reach significance.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(95)01242-7