Humoral immunity in disseminated Aspergillus terreus infection in the dog

Aspects of humoral immunity were studied in 17 dogs with disseminated aspergillosis (16 cases Aspergillus terreus, 1 case Aspergillus flavipes). All dogs had markedly raised serum IgG levels by single radial immunodiffusion (range 1500–6000 mg dl −1). Despite this, serum antibody to A. terreus was d...

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Veröffentlicht in:	Veterinary microbiology 1988-03, Vol.16 (3), p.283-294
Hauptverfasser:	Day, M.J., Penhale, W.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal mycoses Animals Antibodies, Fungal - biosynthesis Antigens, Fungal - immunology Aspergillosis - immunology Aspergillosis - veterinary Aspergillus - immunology Aspergillus terreus Biological and medical sciences Counterimmunoelectrophoresis Dog Diseases - immunology Dogs Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique Immunodiffusion Immunoglobulin G - biosynthesis Immunoglobulins - biosynthesis Infectious diseases Medical sciences Mycoses
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Beschreibung
Zusammenfassung:	Aspects of humoral immunity were studied in 17 dogs with disseminated aspergillosis (16 cases Aspergillus terreus, 1 case Aspergillus flavipes). All dogs had markedly raised serum IgG levels by single radial immunodiffusion (range 1500–6000 mg dl −1). Despite this, serum antibody to A. terreus was demonstrated in only 7 16 cases by agar gel diffusion, 9 16 cases by counter immunoelectrophoresis, 10 16 by ELISA and 11 16 by an indirect immunofluorescence assay. Serum antibody was also detected in 2 5 clinically normal relatives of 2 cases, indicating previous exposure or subclinical infection.
ISSN:	0378-1135 1873-2542
DOI:	10.1016/0378-1135(88)90032-6