Loss of matrix calcium-binding protein-containing neurons in Huntington's disease

Loss of matrix calcium-binding protein-containing neurons in Huntington's disease

In post-mortem brain specimens from patients dying with a clinical diagnosis of Huntington's disease (HD) immunohistochemistry showed a substantial loss from the neostriatum of neurons containing the calcium-binding protein calbindin 28K. These calbindin neurons, and the straital compartment in...

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Veröffentlicht in:The Lancet (British edition) 1988-06, Vol.1 (8597), p.1252-1255
Hauptverfasser: Seto-Ohshima, A, Emson, P C, Lawson, E, Mountjoy, C Q, Carrasco, L H
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Brain Chemistry
Calcium-Binding Proteins - analysis
Corpus Striatum - analysis
Corpus Striatum - pathology
Female
Humans
Huntington Disease - pathology
Immunohistochemistry
Male
Middle Aged
Neurons - analysis
Neurons - pathology
Substantia Nigra - analysis
Substantia Nigra - pathology
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Beschreibung
Zusammenfassung:In post-mortem brain specimens from patients dying with a clinical diagnosis of Huntington's disease (HD) immunohistochemistry showed a substantial loss from the neostriatum of neurons containing the calcium-binding protein calbindin 28K. These calbindin neurons, and the straital compartment in which they are sited, are particularly damaged in HD, suggesting that a failure of calcium buffering or homeostasis may contribute to cell death in HD.
ISSN:0140-6736