Insulin effect on amino acid uptake by unloaded rat hindlimb muscles

The effect of insulin on the uptake of alpha-amino-isobutyric acid (AIB) by unloaded rat hindlimb muscles was investigated using soleus and extensor digitorum longus (EDL) muscles from intact and adrenalectomized (ADX) rats that were tail-casted for six days. It was found that, at insulin levels abo...

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Veröffentlicht in:	Hormone and metabolic research 1988-02, Vol.20 (2), p.125-126
Hauptverfasser:	Jaspers, S. R., Tischler, M. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - pharmacokinetics Aminoisobutyric Acids - pharmacokinetics Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Hindlimb Insulin - pharmacology Life Sciences (General) Male Muscles - metabolism Rats SHORT COMMUNICATIONS Space life sciences Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system
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Zusammenfassung:	The effect of insulin on the uptake of alpha-amino-isobutyric acid (AIB) by unloaded rat hindlimb muscles was investigated using soleus and extensor digitorum longus (EDL) muscles from intact and adrenalectomized (ADX) rats that were tail-casted for six days. It was found that, at insulin levels above 0.00001 units/ml, the in vitro rate of AIB uptake by muscles from intact animals was stimulated more in the weight bearing muscles than in unloaded ones. In ADX animals, this differential response to insulin was abolished.
ISSN:	0018-5043 1439-4286
DOI:	10.1055/s-2007-1010771