A Receptor in Pituitary and Hypothalamus that Functions in Growth Hormone Release

Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial an...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1996-08, Vol.273 (5277), p.974-977
Hauptverfasser:	Howard, Andrew D., Feighner, Scott D., Cully, Doris F., Arena, Joseph P., Liberator, Paul A., Rosenblum, Charles I., Hamelin, Michel, Hreniuk, Donna L., Palyha, Oksana C., Anderson, Jennifer, Paress, Philip S., Diaz, Carmen, Chou, Michael, Liu, Ken K., McKee, Karen Kulju, Pong, Sheng-Shung, Chaung, Lee-Yuh, Elbrecht, Alex, Dashkevicz, Mike, Heavens, Robert, Rigby, Mike, Dalip J. S. Sirinathsinghji, Dean, Dennis C., Melillo, David G., Patchett, Arthur A., Nargund, Ravi, Griffin, Patrick R., DeMartino, Julie A., Gupta, Sunil K., Schaeffer, James M., Smith, Roy G., Lex H. T. van der Ploeg
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Base Sequence Biological and medical sciences Cell Line Cell membranes Codon Complementary DNA Complementary RNA DNA, Complementary - genetics Fundamental and applied biological sciences. Psychology Genes. Genome Growth Hormone - metabolism GTP-Binding Proteins - metabolism Hormones Hormones - metabolism Humans Hypothalamus Hypothalamus, Middle - chemistry Indoles - metabolism Indoles - pharmacology Libraries Ligands Macaca mulatta Molecular and cellular biology Molecular biology Molecular genetics Molecular Sequence Data Oligopeptides - metabolism Oocytes Pharmacology Physical growth Pituitary gland Pituitary Gland - chemistry Proteins Rats Receptors Receptors, Cell Surface - analysis Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, G-Protein-Coupled Receptors, Ghrelin RNA RNA, Complementary - genetics Somatotropin Somatotropin receptors Somatotropin releasing hormone Spiro Compounds - metabolism Spiro Compounds - pharmacology Swine Translation
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Beschreibung
Zusammenfassung:	Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.273.5277.974