Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitors

Aqueous and ethanolic extracts of 39 plants used in traditional Zulu medicine to treat headache or inflammatory diseases were screened for prostaglandin-synthesis inhibitors. Extracts were tested in an in vitro assay for cyclooxygenase inhibitors. In general, ethanolic extracts caused higher inhibit...

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Veröffentlicht in:	Journal of ethnopharmacology 1996-06, Vol.52 (2), p.95-100
Hauptverfasser:	Jäger, Anna K., Hutchings, Anne, van Staden, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Anti-inflammatory Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Cyclooxygenase Cyclooxygenase Inhibitors - isolation & purification Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase Inhibitors - therapeutic use Ethanol - chemistry General pharmacology Headache Headache - drug therapy Indomethacin - pharmacology Inhibitors Male Medical sciences Medicine, African Traditional Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Plant Extracts - therapeutic use Plants, Medicinal Prostaglandin Antagonists - isolation & purification Prostaglandin Antagonists - pharmacology Prostaglandin Antagonists - therapeutic use Prostaglandin-synthesis Prostaglandins - biosynthesis Screening Seminal Vesicles - drug effects Sheep South Africa Water - chemistry
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Beschreibung
Zusammenfassung:	Aqueous and ethanolic extracts of 39 plants used in traditional Zulu medicine to treat headache or inflammatory diseases were screened for prostaglandin-synthesis inhibitors. Extracts were tested in an in vitro assay for cyclooxygenase inhibitors. In general, ethanolic extracts caused higher inhibition than aqueous extracts. Two-thirds of the plants screened had high inhibitory activity. The highest inhibition was obtained with ethanolic extracts of Bidens pilosa, Eucomis autumnalis, Harpephyllum caffrum, Helichrysum nudifolium, Leonotis intermedia, L. leonorus, Ocotea bullata, Rumex saggitatus, Solanum mauritianum, Synadenium cupulare and Trichilia dregeana.
ISSN:	0378-8741 1872-7573
DOI:	10.1016/0378-8741(96)01395-5