Prolongation of male skin graft survival in female mice treated with amniotic fluid

The H-Y antigen is responsible for the rejection of male grafts by otherwise histocompatible female mice of the same inbred strain. In A/J mice, male-to-female skin grafts are rejected by approximately 50% of the recipients, thus providing a sensitive model to study subtle effects of various treatments on graft survival. Using this model system the authors demonstrate in this study that mouse amniotic fluid significantly affects the capacity of female mice to reject male skin.