Partial external diversion of bile for the treatment of intractable pruritus associated with intrahepatic cholestasis

Partial external diversion of bile for the treatment of intractable pruritus associated with intrahepatic cholestasis

Partial diversion of bile flow to an external stoma was performed in 6 patients with chronic intrahepatic cholestasis with severe pruritus that had been refractory to medical measures. Four patients with progressive intrahepatic cholestasis and 2 with arteriohepatic dysplasia were treated. Follow-up...

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Veröffentlicht in:Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1988-07, Vol.95 (1), p.130-136
Hauptverfasser: Whitington, Peter F., Whitington, Gene L.
Format: Artikel
Sprache:eng
Schlagworte:
Abnormalities, Multiple
Bile
Bile Acids and Salts - blood
Bile Ducts, Intrahepatic - abnormalities
Biliary Tract Surgical Procedures
Bilirubin - blood
Biological and medical sciences
Child, Preschool
Cholestasis, Intrahepatic - blood
Cholestasis, Intrahepatic - complications
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Other diseases. Semiology
Pruritus - etiology
Pruritus - therapy
Syndrome
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Zusammenfassung:Partial diversion of bile flow to an external stoma was performed in 6 patients with chronic intrahepatic cholestasis with severe pruritus that had been refractory to medical measures. Four patients with progressive intrahepatic cholestasis and 2 with arteriohepatic dysplasia were treated. Follow-up has been 3–8 yr. Patients with progressive intrahepatic cholestasis have been free of itching since surgery. Serum bile salt concentrations fell from 218–275 μM (normal < 10) before to
ISSN:0016-5085
1528-0012
DOI:10.1016/0016-5085(88)90301-0