Mapping the homolog of the human Rb1 gene to chromosome 14 of higher primates

Mapping the homolog of the human Rb1 gene to chromosome 14 of higher primates

The Rb1 gene has been implicated with retinoblastoma and is located on human Chromosome (Chr) 13q14.2. A unique sequence human Rb1 cosmid DNA probe has been used to localize this region on apes' Chr 14 by the FISH technique. The conservation of the Rb1 gene in higher primates at the correspondi...

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Veröffentlicht in:Mammalian genome 1996-08, Vol.7 (8), p.591-592
Hauptverfasser: Verma, R S, Ramesh, K H, Samonte, R V, Conte, R A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological Evolution
Chromosome Mapping
Chromosomes, Human, Pair 1
DNA Probes
Genes, Retinoblastoma
Gorilla gorilla
Homo sapiens
Humans
Pan troglodytes
Phylogeny
Pongo pygmaeus
primates
Primates - genetics
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Beschreibung
Zusammenfassung:The Rb1 gene has been implicated with retinoblastoma and is located on human Chromosome (Chr) 13q14.2. A unique sequence human Rb1 cosmid DNA probe has been used to localize this region on apes' Chr 14 by the FISH technique. The conservation of the Rb1 gene in higher primates at the corresponding equivalent chromosome locus (14q14) of the human may serve as a phylogenetic marker to further trace the evolutionary pathway of human descent.
ISSN:0938-8990
1432-1777
DOI:10.1007/s003359900175