The effect of food on the systemic availability of ketoprofen

The effect of food on the systemic availability of ketoprofen

We have studied the pharmacokinetics of ketoprofen, a non-steroidal anti-inflammatory drug, in 12 patients after a single 100 mg oral dose both in fasting conditions and with a meal. Food significantly affected the peak plasma concentration of ketoprofen and decreased its absorption rate. However, t...

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Veröffentlicht in:European journal of clinical pharmacology 1988-01, Vol.33 (6), p.643-645
Hauptverfasser: BANNWARTH, B, LAPICQUE, F, NETTER, P, MONOT, C, TAMISIER, J. N, THOMAS, P, ROYER, R. J
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Adult
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Dosage Forms
Female
Food
Humans
Ketoprofen - administration & dosage
Ketoprofen - pharmacokinetics
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Phenylpropionates - pharmacokinetics
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Zusammenfassung:We have studied the pharmacokinetics of ketoprofen, a non-steroidal anti-inflammatory drug, in 12 patients after a single 100 mg oral dose both in fasting conditions and with a meal. Food significantly affected the peak plasma concentration of ketoprofen and decreased its absorption rate. However, the extent of absorption of ketoprofen, as reflected by the area under the plasma concentration time curve, appeared to be unchanged in the presence of food.
ISSN:0031-6970
1432-1041
DOI:10.1007/bf00542503