Anti-HIV Triterpene Acids from Geum japonicum

The methanol extract from the whole plant of Geum japonicum was found to inhibit the human immunodeficiency virus (HIV-1) protease. Through bioassay-directed fractionation of the extract, a new triterpene acid along with five known triterpene acids, ursolic acid, epipomolic acid, maslinic acid, eusc...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1996-07, Vol.59 (7), p.643-645
Hauptverfasser:	Xu, Hong-Xi, Zeng, Fa-Quan, Wan, Min, Sim, Keng-Yeow
Format:	Artikel
Sprache:	eng
Schlagworte:	ACIDE ORGANIQUE ACIDOS ORGANICOS AIDS/HIV Amino Acid Sequence Antibiotics. Antiinfectious agents. Antiparasitic agents ANTIMICROBIAL PROPERTIES Antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology ANTIVIRAL PROPERTIES Biological and medical sciences CHEMICAL COMPOSITION CHEMICAL STRUCTURE CHINA CHINE COMPOSICION QUIMICA COMPOSITION CHIMIQUE DRUG PLANTS ENZYME INHIBITORS EPIPOMOLIC ACID ESPECTROMETRIA ESTRUCTURA QUIMICA EUSCAPHIC ACID General pharmacology GENERO HUMANO GENRE HUMAIN HERPETOVIRIDAE HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - pharmacology HIV-1 - drug effects HIV-1 - enzymology HUMAN IMMUNODEFICIENCY VIRUS human immunodeficiency virus 1 Humans INHIBIDORES DE ENZIMAS INHIBITEUR D'ENZYME Magnetic Resonance Spectroscopy MANKIND MASLINIC ACID Medical sciences Molecular Sequence Data ORGANIC ACIDS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments PLANTAS MEDICINALES PLANTE MEDICINALE Plants, Medicinal - chemistry PROPIEDADES ANTIMICROBIANAS PROPRIETE ANTIMICROBIENNE PROTEASAS PROTEASE PROTEASES ROSACEAE SAPOGENINAS SAPOGENINE SAPOGENINS SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY STRUCTURE CHIMIQUE TORMENTIC ACID Triterpenes - chemistry Triterpenes - pharmacology TRITERPENOIDE TRITERPENOIDOS TRITERPENOIDS URSOLIC ACID
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Beschreibung
Zusammenfassung:	The methanol extract from the whole plant of Geum japonicum was found to inhibit the human immunodeficiency virus (HIV-1) protease. Through bioassay-directed fractionation of the extract, a new triterpene acid along with five known triterpene acids, ursolic acid, epipomolic acid, maslinic acid, euscaphic acid, and tormentic acid, were isolated. The structure of the new compound was determined by spectral means including 1H−H COSY, HMQC, HMBC, and NOE experiments to be 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (1). Of these compounds, 1, ursolic acid, and maslinic acid showed potent inhibitory activity against HIV-1 protease.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np960165e