Association between Prior Cytomegalovirus Infection and the Risk of Restenosis after Coronary Atherectomy
Neointimal hyperplasia and arterial remodeling cause restenosis in 20 to 50 percent of patients who have undergone coronary angioplasty. 1 , 2 Although the mechanisms are unknown, previous findings have raised the possibility that cytomegalovirus (CMV) contributes to the development of restenosis in...
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| Veröffentlicht in: | The New England journal of medicine 1996-08, Vol.335 (9), p.624-630 |
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| container_title | The New England journal of medicine |
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| creator | Zhou, Yi Fu Leon, Martin B Waclawiw, Myron A Popma, Jeffery J Yu, Zu Xi Finkel, Toren Epstein, Stephen E |
| description | Neointimal hyperplasia and arterial remodeling cause restenosis in 20 to 50 percent of patients who have undergone coronary angioplasty.
1
,
2
Although the mechanisms are unknown, previous findings have raised the possibility that cytomegalovirus (CMV) contributes to the development of restenosis in some patients.
3
In approximately one third of patients with restenosis, the lesions contain CMV DNA sequences. Smooth-muscle cells grown from such lesions express IE84, one of the virus's immediate early proteins, and IE84 binds to and inhibits the p53 tumor-suppressor gene product. These effects may enhance the proliferation of smooth-muscle cells or inhibit apoptosis, either of which may contribute . . . |
| doi_str_mv | 10.1056/NEJM199608293350903 |
| format | Article |
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1
,
2
Although the mechanisms are unknown, previous findings have raised the possibility that cytomegalovirus (CMV) contributes to the development of restenosis in some patients.
3
In approximately one third of patients with restenosis, the lesions contain CMV DNA sequences. Smooth-muscle cells grown from such lesions express IE84, one of the virus's immediate early proteins, and IE84 binds to and inhibits the p53 tumor-suppressor gene product. These effects may enhance the proliferation of smooth-muscle cells or inhibit apoptosis, either of which may contribute . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199608293350903</identifier><identifier>PMID: 8687516</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Aged ; Angioplasty ; Antibodies, Viral - blood ; Apoptosis ; Atherectomy, Coronary ; Biological and medical sciences ; Cell cycle ; Cineangiography ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - surgery ; Coronary Artery Disease - virology ; Coronary Disease - diagnostic imaging ; Coronary Disease - surgery ; Coronary Disease - virology ; Cytomegalovirus ; Cytomegalovirus - immunology ; Cytomegalovirus Infections - complications ; Cytomegalovirus Infections - immunology ; Female ; Gene expression ; Hepatitis Antibodies - blood ; Hepatovirus - immunology ; Humans ; Immunoglobulin G - blood ; Linear Models ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Patients ; Prospective Studies ; Recurrence ; Risk Factors ; Serologic Tests ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart</subject><ispartof>The New England journal of medicine, 1996-08, Vol.335 (9), p.624-630</ispartof><rights>Copyright © 1996 Massachusetts Medical Society. All rights reserved.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-8eecb330deb246fd74d92f1045621b8db8392711a0aca6e88d73a654d3c1c8603</citedby><cites>FETCH-LOGICAL-c590t-8eecb330deb246fd74d92f1045621b8db8392711a0aca6e88d73a654d3c1c8603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199608293350903$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223978287?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,2746,2747,26084,27905,27906,52363,54045,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3203838$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8687516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Yi Fu</creatorcontrib><creatorcontrib>Leon, Martin B</creatorcontrib><creatorcontrib>Waclawiw, Myron A</creatorcontrib><creatorcontrib>Popma, Jeffery J</creatorcontrib><creatorcontrib>Yu, Zu Xi</creatorcontrib><creatorcontrib>Finkel, Toren</creatorcontrib><creatorcontrib>Epstein, Stephen E</creatorcontrib><title>Association between Prior Cytomegalovirus Infection and the Risk of Restenosis after Coronary Atherectomy</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Neointimal hyperplasia and arterial remodeling cause restenosis in 20 to 50 percent of patients who have undergone coronary angioplasty.
1
,
2
Although the mechanisms are unknown, previous findings have raised the possibility that cytomegalovirus (CMV) contributes to the development of restenosis in some patients.
3
In approximately one third of patients with restenosis, the lesions contain CMV DNA sequences. Smooth-muscle cells grown from such lesions express IE84, one of the virus's immediate early proteins, and IE84 binds to and inhibits the p53 tumor-suppressor gene product. These effects may enhance the proliferation of smooth-muscle cells or inhibit apoptosis, either of which may contribute . . .</description><subject>Adult</subject><subject>Aged</subject><subject>Angioplasty</subject><subject>Antibodies, Viral - blood</subject><subject>Apoptosis</subject><subject>Atherectomy, Coronary</subject><subject>Biological and medical sciences</subject><subject>Cell cycle</subject><subject>Cineangiography</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - surgery</subject><subject>Coronary Artery Disease - virology</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - surgery</subject><subject>Coronary Disease - virology</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - immunology</subject><subject>Cytomegalovirus Infections - complications</subject><subject>Cytomegalovirus Infections - immunology</subject><subject>Female</subject><subject>Gene expression</subject><subject>Hepatitis Antibodies - blood</subject><subject>Hepatovirus - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Linear Models</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Recurrence</subject><subject>Risk Factors</subject><subject>Serologic Tests</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1v1DAQhq2KqixLf0GFZKGKC0rxR-LYx9WqhVZtQRWcI8eZFC-J3XoSqv33GHbVA0LMHOYwzzufhJxwdsZZpT7cnl_dcGMU08JIWTHD5AFZ8ErKoiyZekEWjAldlLWRL8krxA3LxktzRI600nXF1YL4FWJ03k4-BtrC9AQQ6JfkY6Lr7RRHuLdD_OnTjPQy9OD-cDZ0dPoO9M7jDxp7egc4QYjokdp-giyNKQabtnSVsZRVcdy-Joe9HRCO93FJvl2cf11_Kq4_f7xcr64LVxk2FRrAtVKyDlpRqr6ry86InrOyUoK3umu1NKLm3DLrrAKtu1paVZWddNxpxeSSvNvVfUjxcc6TNaNHB8NgA8QZm1oLLmS-2JK8_QvcxDmFPFsjhDSZ03WG5A5yKSIm6JuH5Me8WsNZ8_sLzT--kFVv9qXndoTuWbM_e86f7vMWnR36ZIPz-IxJwaTOviTvd9g4YhNgM_636S_y5Zv9</recordid><startdate>19960829</startdate><enddate>19960829</enddate><creator>Zhou, Yi Fu</creator><creator>Leon, Martin B</creator><creator>Waclawiw, Myron A</creator><creator>Popma, Jeffery J</creator><creator>Yu, Zu Xi</creator><creator>Finkel, Toren</creator><creator>Epstein, Stephen E</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19960829</creationdate><title>Association between Prior Cytomegalovirus Infection and the Risk of Restenosis after Coronary Atherectomy</title><author>Zhou, Yi Fu ; Leon, Martin B ; Waclawiw, Myron A ; Popma, Jeffery J ; Yu, Zu Xi ; Finkel, Toren ; Epstein, Stephen E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-8eecb330deb246fd74d92f1045621b8db8392711a0aca6e88d73a654d3c1c8603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Angioplasty</topic><topic>Antibodies, Viral - blood</topic><topic>Apoptosis</topic><topic>Atherectomy, Coronary</topic><topic>Biological and medical sciences</topic><topic>Cell cycle</topic><topic>Cineangiography</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - surgery</topic><topic>Coronary Artery Disease - virology</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - surgery</topic><topic>Coronary Disease - virology</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus - immunology</topic><topic>Cytomegalovirus Infections - complications</topic><topic>Cytomegalovirus Infections - immunology</topic><topic>Female</topic><topic>Gene expression</topic><topic>Hepatitis Antibodies - blood</topic><topic>Hepatovirus - immunology</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Linear Models</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Patients</topic><topic>Prospective Studies</topic><topic>Recurrence</topic><topic>Risk Factors</topic><topic>Serologic Tests</topic><topic>Surgery (general aspects). 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1
,
2
Although the mechanisms are unknown, previous findings have raised the possibility that cytomegalovirus (CMV) contributes to the development of restenosis in some patients.
3
In approximately one third of patients with restenosis, the lesions contain CMV DNA sequences. Smooth-muscle cells grown from such lesions express IE84, one of the virus's immediate early proteins, and IE84 binds to and inhibits the p53 tumor-suppressor gene product. These effects may enhance the proliferation of smooth-muscle cells or inhibit apoptosis, either of which may contribute . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>8687516</pmid><doi>10.1056/NEJM199608293350903</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1996-08, Vol.335 (9), p.624-630 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78212329 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adult Aged Angioplasty Antibodies, Viral - blood Apoptosis Atherectomy, Coronary Biological and medical sciences Cell cycle Cineangiography Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - surgery Coronary Artery Disease - virology Coronary Disease - diagnostic imaging Coronary Disease - surgery Coronary Disease - virology Cytomegalovirus Cytomegalovirus - immunology Cytomegalovirus Infections - complications Cytomegalovirus Infections - immunology Female Gene expression Hepatitis Antibodies - blood Hepatovirus - immunology Humans Immunoglobulin G - blood Linear Models Logistic Models Male Medical sciences Middle Aged Multivariate Analysis Patients Prospective Studies Recurrence Risk Factors Serologic Tests Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart |
| title | Association between Prior Cytomegalovirus Infection and the Risk of Restenosis after Coronary Atherectomy |
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