Association between Prior Cytomegalovirus Infection and the Risk of Restenosis after Coronary Atherectomy

Neointimal hyperplasia and arterial remodeling cause restenosis in 20 to 50 percent of patients who have undergone coronary angioplasty. 1 , 2 Although the mechanisms are unknown, previous findings have raised the possibility that cytomegalovirus (CMV) contributes to the development of restenosis in...

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Veröffentlicht in:The New England journal of medicine 1996-08, Vol.335 (9), p.624-630
Hauptverfasser: Zhou, Yi Fu, Leon, Martin B, Waclawiw, Myron A, Popma, Jeffery J, Yu, Zu Xi, Finkel, Toren, Epstein, Stephen E
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Sprache:eng
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Zusammenfassung:Neointimal hyperplasia and arterial remodeling cause restenosis in 20 to 50 percent of patients who have undergone coronary angioplasty. 1 , 2 Although the mechanisms are unknown, previous findings have raised the possibility that cytomegalovirus (CMV) contributes to the development of restenosis in some patients. 3 In approximately one third of patients with restenosis, the lesions contain CMV DNA sequences. Smooth-muscle cells grown from such lesions express IE84, one of the virus's immediate early proteins, and IE84 binds to and inhibits the p53 tumor-suppressor gene product. These effects may enhance the proliferation of smooth-muscle cells or inhibit apoptosis, either of which may contribute . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199608293350903