VLDL apoprotein secretion and apo-B mRNA level in primary culture of cholesterol-loaded rabbit hepatocytes

Incubation of cultured rabbit hepatocytes with β very low density lipoproteins (β-VLDL) induces a dose-dependent increase in cell cholesterol (CH) content and VLDL apoprotein (apo) B and E secretion without change in apo-B mRNA level. These data suggest that β-VLDL may exert a stimulatory effect on...

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Veröffentlicht in:	FEBS letters 1988-05, Vol.232 (1), p.103-106
Hauptverfasser:	Kosykh, V.A., Surguchov, A.P., Podres, E.A., Novikov, D.K., Sudarickov, A.B., Berestetskaya, Yu.V., Repin, V.S., Smirnov, V.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apo, apoprotein Apolipoprotein B Apolipoproteins B - genetics Apolipoproteins B - metabolism Apolipoproteins E - metabolism Apoproteins - metabolism Biological and medical sciences Cells, Cultured CH, cholesterol Cholesterol Cholesterol - metabolism Cholesterol - pharmacology ECH, cholesterol esters Fundamental and applied biological sciences. Psychology Lipoproteins, VLDL - metabolism Liver - drug effects Liver - metabolism Liver. Bile. Biliary tracts mRNA Nucleic Acid Hybridization Rabbit hepatocyte Rabbits RNA, Messenger - metabolism Vertebrates: digestive system VLDL secretion β-VLDL β-VLDL, beta very low density lipoproteins
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Zusammenfassung:	Incubation of cultured rabbit hepatocytes with β very low density lipoproteins (β-VLDL) induces a dose-dependent increase in cell cholesterol (CH) content and VLDL apoprotein (apo) B and E secretion without change in apo-B mRNA level. These data suggest that β-VLDL may exert a stimulatory effect on hepatic apo-B production at the co-translational and/or posttranslational level.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(88)80395-8