The prostaglandin response in guinea-pig taenia caeci and trachea smooth muscle of different ages

The concentration-response curves for the carbachol-induced contraction of smooth muscle cells of guinea-pig taenia caeci and trachea were not dependent on tissue age. The prostaglandin E 2 and F 2α responses increased with age in taenia caeci in contrast with the PGE 2 response evoked in trachea. T...

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Veröffentlicht in:	European journal of pharmacology 1988-03, Vol.147 (2), p.273-277
Hauptverfasser:	Vermue, Niek A., Hertog, Adriaan Den
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging - metabolism Animals Biological and medical sciences Carbachol - pharmacology Cecum - drug effects Cecum - metabolism Dinoprost Dinoprostone Guinea Pigs In Vitro Techniques Ion Channels - physiology Medical sciences Muscle Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - metabolism Pharmacology. Drug treatments Prostaglandins Prostaglandins - biosynthesis Prostaglandins E - biosynthesis Prostaglandins F - biosynthesis Smooth muscle Taenia caeci Trachea Trachea - drug effects Trachea - metabolism Verapamil - pharmacology
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Zusammenfassung:	The concentration-response curves for the carbachol-induced contraction of smooth muscle cells of guinea-pig taenia caeci and trachea were not dependent on tissue age. The prostaglandin E 2 and F 2α responses increased with age in taenia caeci in contrast with the PGE 2 response evoked in trachea. The high-potassium responses evoked in taenia caeci and trachea both increased at higher tissue age. Methoxyverapamil only inhibited the age-depeadent responses. The results suggest that it is mainly the voltage-dependent calcium channels that are involved in the age-dependent prostaglandin response.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(88)90786-8