Structure−Activity Relationships of (E)-3-(1,4-Benzoquinonyl)-2-[(3-pyridyl)- alkyl]-2-propenoic Acid Derivatives That Inhibit Both 5-Lipoxygenase and Thromboxane A2 Synthetase

As part of our research for the development of novel antiinflammatory drug candidates, we have designed and synthesized a series of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)alkyl]-2-propenoic acid derivatives as dual inhibitors of 5-lipoxygenase (5-LO) and thromboxane (TX) A2 synthetase. In order to...

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Veröffentlicht in:Journal of medicinal chemistry 1996-08, Vol.39 (16), p.3148-3157
Hauptverfasser: Hibi, Shigeki, Okamoto, Yasushi, Tagami, Katsuya, Numata, Hirotoshi, Kobayashi, Naoki, Shinoda, Masanobu, Kawahara, Tetsuya, Harada, Koukichi, Miyamoto, Kaname, Yamatsu, Isao
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Sprache:eng
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