CHEMICAL MODIFICATION OF STEFFIMYCIN B

CHEMICAL MODIFICATION OF STEFFIMYCIN B

Fifteen 3-substituted analogues of steffimycin B (1) have been synthesized and their activity against P388 murine leukemia has been determined. Three of these were substantially more active than the parent compound.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of antibiotics 1988/03/25, Vol.41(3), pp.343-351
Hauptverfasser: WILEY, PAUL F., ELROD, DAVID W., HARPER, DONALD E.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anthracyclines
Antibiotics, Antineoplastic - pharmacology
Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides
Carbohydrates. Nucleosides and nucleotides
Chemistry
Exact sciences and technology
Leukemia P388 - drug therapy
Naphthacenes - pharmacology
Organic chemistry
Preparations and properties
Structure-Activity Relationship
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Fifteen 3-substituted analogues of steffimycin B (1) have been synthesized and their activity against P388 murine leukemia has been determined. Three of these were substantially more active than the parent compound.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.41.343