CONCENTRATIONS OF CEFUROXIME IN THE SKIN

CONCENTRATIONS OF CEFUROXIME IN THE SKIN

Concentrations of cefuroxime (CXM) in the skin and the serum of 24 patients were examined. CXM (0.75g, 1.5g) was administered to these patients intravenously in one shot. The skin and the serum were collected at 30 and 60 minutes after the injection. Concentrations of CXM in the skin were following:...

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Veröffentlicht in:Japanese journal of antibiotics 1988/01/25, Vol.41(1), pp.10-17
Hauptverfasser: HARA, TOHRU, SAEKI, HIDEAKI, YAMAMOTO, AKIRA, OHTA, KATSUYA, SUZUKI, TAKAHARU, ARA, MICHITO, SUGAWARA, MITSUO, SANO, YUTAKA, SAKUMA, HIDEO, SATOH, KIMIKO
Format: Artikel
Sprache:jpn
Schlagworte:
Cefuroxime - administration & dosage
Cefuroxime - blood
Cefuroxime - pharmacokinetics
Cephalosporins - pharmacokinetics
Female
Humans
Injections, Intravenous
Male
Skin - metabolism
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Zusammenfassung:Concentrations of cefuroxime (CXM) in the skin and the serum of 24 patients were examined. CXM (0.75g, 1.5g) was administered to these patients intravenously in one shot. The skin and the serum were collected at 30 and 60 minutes after the injection. Concentrations of CXM in the skin were following: 0.75g, 30min.; 11.4±5.3μg/g 60min.; 9.5± 4.7μμg/g 1.5g, 30min.; 17.1±6.8μg/g 60min.; 15.7±13.2μg/g Concentration ratios (skin/serum) at 60 minutes after the injection were from 72.5% to 79.2%. The binding ratio of CXM to serum protein was 41%, which was lower than most other antibiotics. High concentration levels of CXM were maintained in the skin for a long time. Based on this study, we consider that CXM is effective in the skin surgery.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.41.10