Influence of cationic superoxide generation enhancing protein (SGEP) on phagocytic and intracellular bactericidal activity of human polymorphonuclear cells
Cationic fraction III from the lysosomes of normal human peripheral blood polymorphonuclear cells (PMNs) was found to contain superoxide generation enhancing protein (SGEP). Herein, we report on the influence of partially purified SGEP obtained from fraction III (subfractions III-5 and III-6), on va...
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| Veröffentlicht in: | Inflammation 1988-02, Vol.12 (1), p.99-106 |
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| creator | PRUZANSKI, W SAITO, S MAHBOOB ALAM RANADIVE, N. S |
| description | Cationic fraction III from the lysosomes of normal human peripheral blood polymorphonuclear cells (PMNs) was found to contain superoxide generation enhancing protein (SGEP). Herein, we report on the influence of partially purified SGEP obtained from fraction III (subfractions III-5 and III-6), on various phagocytic functions of human PMNs. SGEP markedly enhanced intracellular bactericidal activity of human peripheral PMNs. The enhancement was time and dose dependent. It also reduced adhesiveness of the PMNs. SGEP did not influence chemotaxis, phagocytosis or phagocytic index. These findings are compatible with our original observation regarding superoxide generation enhancement properties of SGEP. |
| doi_str_mv | 10.1007/BF00915895 |
| format | Article |
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These findings are compatible with our original observation regarding superoxide generation enhancement properties of SGEP.</description><subject>Biological and medical sciences</subject><subject>Blood Bactericidal Activity</subject><subject>Blood Proteins - physiology</subject><subject>Cations</subject><subject>Cell Adhesion</subject><subject>Chemotaxis, Leukocyte</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>In Vitro Techniques</subject><subject>Lysosomes - physiology</subject><subject>Myeloid cells: ontogeny, maturation, markers, receptors</subject><subject>Neutrophils - physiology</subject><subject>Phagocytosis</subject><subject>Superoxides - biosynthesis</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFSEUhonR1Nvqxr0JC2PUZJSPmQGWtelX0qQm6nrCMId7MQyMMGO8v8U_W8betMuuILzPe4A8CL2h5DMlRHz5ekGIoo1UzTO0oY3gFWtE-xxtCG9JxZUSL9Fxzr8IIVJJfoSOmOQNZ3SD_l0H6xcIBnC02OjZxeAMzssEKf51A-AtBEj_zzGEnQ7GhS2eUpzBBfzh--X5t4-4ZNNOb6PZz6Wsw4BdmJM24P3idcK9NjMkZ9ygPS5798fN-_XC3TLq0o1-P8Y07WJYjIdSWJv5FXphtc_w-rCeoJ8X5z_Orqqb28vrs9ObyvCazZWwxmheD0TKljNpamZBW8V1K5WCwWqgtuc9U02jBtrXveDMNLSXEsDW3PIT9P5-bvnV7wXy3I0ury_QAeKSOyEZ4UzQJ0FaFwu1qgv46R40KeacwHZTcqNO-46SblXWPSor8NvD1KUfYXhAD45K_u6Q62y0t2l1kB8w0bK2bhS_A9jHoZ4</recordid><startdate>19880201</startdate><enddate>19880201</enddate><creator>PRUZANSKI, W</creator><creator>SAITO, S</creator><creator>MAHBOOB ALAM</creator><creator>RANADIVE, N. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>In Vitro Techniques</topic><topic>Lysosomes - physiology</topic><topic>Myeloid cells: ontogeny, maturation, markers, receptors</topic><topic>Neutrophils - physiology</topic><topic>Phagocytosis</topic><topic>Superoxides - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PRUZANSKI, W</creatorcontrib><creatorcontrib>SAITO, S</creatorcontrib><creatorcontrib>MAHBOOB ALAM</creatorcontrib><creatorcontrib>RANADIVE, N. 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S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of cationic superoxide generation enhancing protein (SGEP) on phagocytic and intracellular bactericidal activity of human polymorphonuclear cells</atitle><jtitle>Inflammation</jtitle><addtitle>Inflammation</addtitle><date>1988-02-01</date><risdate>1988</risdate><volume>12</volume><issue>1</issue><spage>99</spage><epage>106</epage><pages>99-106</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><coden>INFLD4</coden><abstract>Cationic fraction III from the lysosomes of normal human peripheral blood polymorphonuclear cells (PMNs) was found to contain superoxide generation enhancing protein (SGEP). Herein, we report on the influence of partially purified SGEP obtained from fraction III (subfractions III-5 and III-6), on various phagocytic functions of human PMNs. SGEP markedly enhanced intracellular bactericidal activity of human peripheral PMNs. The enhancement was time and dose dependent. It also reduced adhesiveness of the PMNs. SGEP did not influence chemotaxis, phagocytosis or phagocytic index. These findings are compatible with our original observation regarding superoxide generation enhancement properties of SGEP.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>2835321</pmid><doi>10.1007/BF00915895</doi><tpages>8</tpages></addata></record> |
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| ispartof | Inflammation, 1988-02, Vol.12 (1), p.99-106 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biological and medical sciences Blood Bactericidal Activity Blood Proteins - physiology Cations Cell Adhesion Chemotaxis, Leukocyte Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology In Vitro Techniques Lysosomes - physiology Myeloid cells: ontogeny, maturation, markers, receptors Neutrophils - physiology Phagocytosis Superoxides - biosynthesis |
| title | Influence of cationic superoxide generation enhancing protein (SGEP) on phagocytic and intracellular bactericidal activity of human polymorphonuclear cells |
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