Influence of cationic superoxide generation enhancing protein (SGEP) on phagocytic and intracellular bactericidal activity of human polymorphonuclear cells

Cationic fraction III from the lysosomes of normal human peripheral blood polymorphonuclear cells (PMNs) was found to contain superoxide generation enhancing protein (SGEP). Herein, we report on the influence of partially purified SGEP obtained from fraction III (subfractions III-5 and III-6), on va...

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Veröffentlicht in:	Inflammation 1988-02, Vol.12 (1), p.99-106
Hauptverfasser:	PRUZANSKI, W, SAITO, S, MAHBOOB ALAM, RANADIVE, N. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Bactericidal Activity Blood Proteins - physiology Cations Cell Adhesion Chemotaxis, Leukocyte Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology In Vitro Techniques Lysosomes - physiology Myeloid cells: ontogeny, maturation, markers, receptors Neutrophils - physiology Phagocytosis Superoxides - biosynthesis
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Zusammenfassung:	Cationic fraction III from the lysosomes of normal human peripheral blood polymorphonuclear cells (PMNs) was found to contain superoxide generation enhancing protein (SGEP). Herein, we report on the influence of partially purified SGEP obtained from fraction III (subfractions III-5 and III-6), on various phagocytic functions of human PMNs. SGEP markedly enhanced intracellular bactericidal activity of human peripheral PMNs. The enhancement was time and dose dependent. It also reduced adhesiveness of the PMNs. SGEP did not influence chemotaxis, phagocytosis or phagocytic index. These findings are compatible with our original observation regarding superoxide generation enhancement properties of SGEP.
ISSN:	0360-3997 1573-2576
DOI:	10.1007/BF00915895