Expression of Protein Encoded by Varicella-Zoster Virus Open Reading Frame 63 in Latently Infected Human Ganglionic Neurons

The ganglionic cell type in which varicella-zoster virus (VZV) is latent in humans was analyzed by using antibodies raised against in vitro-expressed VZV open reading frame 63 protein. VZV open reading frame 63 protein was detected exclusively in the cytoplasm of neurons of latently infected human t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-03, Vol.93 (5), p.2122-2124
Hauptverfasser:	Mahalingam, Ravi, Wellish, Mary, Cohrs, Randall, Debrus, Serge, Piette, Jacques, Rentier, Bernard, Gilden, Donald H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies Cytoplasm DNA Ganglia Ganglia, Sympathetic - microbiology Herpes viruses Herpesvirus 3, Human - metabolism Human health sciences Human herpesvirus 3 Humans Immediate-Early Proteins - metabolism Immunohistochemistry Immunologie & maladie infectieuse Immunology & infectious disease Infant Kidney cells Nervous system Neurons Open reading frames Proteins Sciences de la santé humaine Thoracic ganglia Trans-Activators - metabolism Trigeminal Ganglion - microbiology varicella-zoster virus Viral Envelope Proteins - metabolism Virus Latency Viruses
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Zusammenfassung:	The ganglionic cell type in which varicella-zoster virus (VZV) is latent in humans was analyzed by using antibodies raised against in vitro-expressed VZV open reading frame 63 protein. VZV open reading frame 63 protein was detected exclusively in the cytoplasm of neurons of latently infected human trigeminal and thoracic ganglia. This is, to our knowledge, the first identification of a herpesvirus protein expressed during latency in the human nervous system.
ISSN:	0027-8424 1091-6490 1091-6490
DOI:	10.1073/pnas.93.5.2122