Agonist Binding to Striatal Dopamine Receptors in Aging The Ternary Complex of Receptor and Guanine Nucleotide Binding Regulatory Protein

Agonist Binding to Striatal Dopamine Receptors in Aging The Ternary Complex of Receptor and Guanine Nucleotide Binding Regulatory Protein

What is the nature of the coupling mechanism? High-affinity agonist binding to striatal D-2 DA receptors declines with age. However, not all receptor systems that act through G-proteins have impaired formation of high-affinity agonist binding complexes with age. Receptor coupling to G-proteins is an...

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Veröffentlicht in:Annals of the New York Academy of Sciences 1988-01, Vol.515 (1), p.178-190
Hauptverfasser: SEVERSON, JAMES A., WILCOX, RICHARD E.
Format: Artikel
Sprache:eng
Schlagworte:
Aging - metabolism
Animals
Corpus Striatum - metabolism
Dopamine - physiology
GTP-Binding Proteins - metabolism
Receptors, Dopamine - metabolism
Receptors, Dopamine D2
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Zusammenfassung:What is the nature of the coupling mechanism? High-affinity agonist binding to striatal D-2 DA receptors declines with age. However, not all receptor systems that act through G-proteins have impaired formation of high-affinity agonist binding complexes with age. Receptor coupling to G-proteins is another major factor to consider in cellular responsiveness with age.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1988.tb32982.x