Hyperglycaemia affects proximal gastric motor and sensory function in normal subjects

OBJECTIVE:Hyperglycaemia delays gastric emptying in normal subjects and patients with diabetes mellitus by uncertain mechanisms and may affect the perception of somatic sensations. The effects of hyperglycaemia on the motor function of the proximal stomach and the perception of gastric distension were evaluated in normal subjects. DESIGN:Paired studies were performed in randomized order in 10 healthy volunteers on separate days during euglycaemia and hyperglycaemia (blood glucose ≈ 15mmol/l). METHODS:With a barostat and a balloon positioned in the proximal stomach, fasting subjects underwent a stepwise gastric distension. Each 2mmHg step was maintained at a constant pressure for 2min. The volume of the barostat balloon was measured and perception of the sensations of fullness, desire to belch, nausea, abdominal discomfort and hunger was scored at each step. RESULTS:Hyperglycaemia was associated with an increase in proximal gastric compliance (P